84558-94-1Relevant articles and documents
2′-De-oxy-5-propynyluridine: A nucleoside with two conformations in the asymmetric unit
Budow, Simone,Eickmeier, Henning,Reuter, Hans,Seela, Frank
, p. o645-o648 (2009)
The title compound, 1-(2-de-oxy-Β-d-erythro-pentofuranos-yl)-5-(prop- 1-yn-yl)pyrimidin-2,4(1H,3H)-dione, C12H14N 2O5, shows two conformations in the crystalline state: conformer 1 adopts a C2′-endo (close to 2 E; S-type) sugar pucker and an anti nucleobase orientation [χ = -134.04 (19)°], while conformer 2 shows an S sugar pucker (twisted C2′-endo-C3′-exo), which is accompanied by a different anti base orientation [χ = -162.79 (17)°]. Both mol-ecules show a +sc (gauche, gauche) conformation at the exocyclic C4′ - C5′ bond and a coplanar orientation of the propynyl group with respect to the pyrimidine ring. The extended structure is a three-dimensional hydrogen-bond network involving intermolecular N - H...O and O - H...O hydrogen bonds. Only O atoms function as H-atom acceptor sites.
Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: A general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group
Hosoya, Takamitsu,Wakao, Masahiro,Kondo, Yurie,Doi, Hisashi,Suzuki, Masaaki
, p. 24 - 27 (2007/10/03)
The Pd(0)-mediated rapid coupling (trapping) reaction of methyl iodide with an excess amount of alkynyltributyl-stannane has been developed with the aim to incorporate a short-lived 11C-labeled methyl group into biologically active organic compounds with a 1-propynyl structural unit.
Synthesis and some biochemical properties of a novel 5,6,7,8-tetrahydropyrimido[4,5-c]pyridazine nucleoside
Loakes, David,Brown, Daniel M.,Salisbury, Stephen A.,McDougall, Mark G.,Neagu, Constantin,Nampalli, Satyam,Kumar, Shiv
, p. 1193 - 1204 (2007/10/03)
A novel nucleoside analogue is described based on the pyridazine ring system. The nucleoside was successfully incorporated into DNA via both its phosphoramidite and 5′-triphosphate derivatives. Enzymatically, the analogue behaves essentially as thymidine: