845827-13-6

Basic information

• Product Name: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-
• Synonyms: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-;5-Bromo-alpha,alpha-difluoro-2-picoline;3-Bromo-6-(difluoromethyl)pyridine;5-Bromo-2-(difluoromethyl)pyridine 95%
• CAS NO: 845827-13-6
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.005
• EINECS: 200-258-5
• Mol File: 845827-13-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 35-40℃
• Boiling Point: 206.644 °C at 760 mmHg
• Flash Point: 89°(192°F)
• Appearance: White to yellow/Solid
• Density: 1.64
• Storage Temp.: 2-8°C
• PKA: -0.83±0.29(Predicted)
• CAS DataBase Reference: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(845827-13-6)
• EPA Substance Registry System: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(845827-13-6)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 845827-13-6(Hazardous Substances Data)

Usage

General Description

PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- is a chemical compound with the molecular formula C6H3BrF2N. It is a brominated pyridine derivative that contains a difluoromethyl group. PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)- is commonly used in organic synthesis and as a building block in pharmaceutical manufacturing. It may also have potential applications in agrochemicals and materials science. It is important to handle this chemical with caution as it may have hazardous properties and should be used in accordance with safety protocols and regulations.

Upstream product

• 294181-95-6 2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester 
• 223463-13-6 2-iodo-5-bromopyridine 
• 1438388-96-5 tributyl(difluoromethyl)stannane 
• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 

Downstream Products

• 845826-93-9 4-[6-(difluoromethyl)-pyridin-3-yl]benzenecarboxylic acid 

Relevant articles and documents

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.