847039-05-8Relevant articles and documents
Rational Design, Synthesis, and Pharmacological Characterization of Novel Ghrelin Receptor Inverse Agonists as Potential Treatment against Obesity-Related Metabolic Diseases
Daina, Antoine,Giuliano, Claudio,Pietra, Claudio,Wang, Junbo,Chi, Yushi,Zou, Zack,Li, Fugang,Yan, Zhonghua,Zhou, Yifan,Guainazzi, Angelo,Garcia Rubio, Silvina,Zoete, Vincent
, p. 11039 - 11060 (2018/10/24)
A new chemotype of ghrelin inverse agonists was discovered through chimeric design based on molecular scaffolds known as growth-hormone secretagogue receptor (GHSR) modulators but with divergent pharmacodynamic and pharmacokinetic properties. The structur
SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE
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, (2015/06/03)
The present invention provides novel heterocyclic compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a JAK-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of JAK-mediated disease.
Substituted triazole derivatives as oxytocin antagonists
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Page/Page column 32, (2008/06/13)
The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.