851341-36-1

Basic information

• Product Name: 1-Methoxymethoxy-2-(trifluoromethoxy)benzene
• Synonyms: 1-Methoxymethoxy-2-(trifluoromethoxy)benzene;Benzene,1-(MethoxyMethoxy)-2-(trifluoroMethoxy)-
• CAS NO: 851341-36-1
• Molecular Formula: C₉H₉F₃O₃
• Molecular Weight: 222.1611696
• Product Categories: Aromatic Halides (substituted)
• Mol File: 851341-36-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methoxymethoxy-2-(trifluoromethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methoxymethoxy-2-(trifluoromethoxy)benzene(851341-36-1)
• EPA Substance Registry System: 1-Methoxymethoxy-2-(trifluoromethoxy)benzene(851341-36-1)

Safety Data

• Hazardous Substances Data: 851341-36-1(Hazardous Substances Data)

Usage

General Description

1-Methoxymethoxy-2-(trifluoromethoxy)benzene is a chemical compound with the molecular formula C9H9F3O3. It is a benzene derivative containing methoxy and trifluoromethoxy functional groups. 1-Methoxymethoxy-2-(trifluoromethoxy)benzene is used in the field of organic chemistry as a reagent for the synthesis of various organic compounds. It is also used as a building block in the development of pharmaceuticals and agrochemicals. The trifluoromethoxy group is known for its electron-withdrawing properties, making this compound potentially useful in the design of new molecules for various applications. However, it is important to handle this chemical with care, as it can be hazardous if not used properly and in a controlled environment.

Upstream product

• 32858-93-8 2-(trifluoromethoxy)phenol 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 1144501-89-2 1-(2-hydroxy-3-(trifluoromethoxy)phenyl)ethanone 
• 1285576-15-9 3-(3-cyano-4-methoxy-5-trifluoromethoxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole 
• 1285576-13-7 3-(3-cyano-4-methoxy-5-trifluoromethoxybenzoyl)-2,3-dihydro-1,3-benzothiazole 
• 1285576-11-5 3-cyano-4-methoxy-5-trifluoromethoxybenzoyl chloride 
• 1285576-09-1 3-cyano-4-methoxy-5-trifluoromethoxybenzoic acid 
• 1285576-08-0 3-formyl-4-methoxy-5-trifluoromethoxybenzoic acid 
• 1285576-07-9 5-bromo-1-diethoxymethyl-2-methoxy-3-trifluoromethoxybenzene 
• 1285576-04-6 5-bromo-2-methoxy-3-trifluoromethoxybenzaldehyde 
• 497959-32-7 5-bromo-2-hydroxy-3-trifluoromethoxybenzaldehyde 
• 1285573-30-9 3-(3-cyano-4-hydroxy-5-trifluoromethoxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole 
• 497959-31-6 2-hydroxy-3-(trifluoromethoxy)benzaldehyde 
• 773873-50-0 2-hydroxy-3-(trifluoromethoxy)benzoic acid 

Relevant articles and documents

TRPV1 Antagonists

Disclosed herein are compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein X1, L, Rx, Ry, Rz, A, m, n, p, q, s, and positions a and b are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

TRPV1 ANTAGONISTS

Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

The site-selective functionalization of halogen-bearing phenols: An exercise in diversity-oriented organometallic synthesis

The organometallic approach to diversity-oriented organic synthesis was subjected to a further test, this time in the phenol series. The model compounds selected were 2,3,6-trifluorophenol, the three isomers of (trifluoromethoxy) phenol and the three isomers of chlorophenol. A combination of optionally site selective metalations and protective group-controlled metalations enabled the selective generation of several isomeric intermediates in each case and their subsequent conversion into functionalized derivatives, in particular hydroxybenzoic acids.