853786-20-6

Basic information

• Product Name: ethyl (E)-3,5-dimethoxy-4-(methoxymethoxy)-cinnamate
• Synonyms: ethyl (E)-3,5-dimethoxy-4-(methoxymethoxy)-cinnamate
• CAS NO: 853786-20-6
• Molecular Weight: 296.32
• Mol File: 853786-20-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (E)-3,5-dimethoxy-4-(methoxymethoxy)-cinnamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (E)-3,5-dimethoxy-4-(methoxymethoxy)-cinnamate(853786-20-6)
• EPA Substance Registry System: ethyl (E)-3,5-dimethoxy-4-(methoxymethoxy)-cinnamate(853786-20-6)

Safety Data

• Hazardous Substances Data: 853786-20-6(Hazardous Substances Data)

Upstream product

• 134-96-3 syringic aldehyde 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 55211-66-0 3,5-dimethoxy-4-(methoxymethoxy)benzaldehyde 

Downstream Products

• 853786-30-8 (2S,3S)-6-[(E)-2-(3,5-Bis-methoxymethoxy-phenyl)-vinyl]-3-(3,5-dimethoxy-4-methoxymethoxy-phenyl)-2-methoxymethoxymethyl-2,3-dihydro-benzo[1,4]dioxine 
• 853786-36-4 (1'R,2'S)-4-benzyloxy-3-[2',3'-epoxy-1'-(3'',5''-dimethoxy-4''-methoxymethoxyphenyl)-propoxy]-benzaldehyde 
• 853786-26-2 (1'S,2'R)-4-benzyloxy-3-[2',3'-epoxy-1'-(3'',5''-dimethoxy-4''-methoxymethoxyphenyl)-propoxy]-benzaldehyde 
• 853786-24-0 Toluene-4-sulfonic acid (2R,3R)-3-(3,5-dimethoxy-4-methoxymethoxy-phenyl)-2,3-dihydroxy-propyl ester 
• 853786-34-2 Toluene-4-sulfonic acid (2S,3S)-3-(3,5-dimethoxy-4-methoxymethoxy-phenyl)-2,3-dihydroxy-propyl ester 
• 853786-29-5 (2S,3S)-3-(3,5-Dimethoxy-4-methoxymethoxy-phenyl)-2-methoxymethoxymethyl-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde 
• 853786-38-6 (2R,3R)-3-(3',5'-dimethoxy-4'-methoxymethoxyphenyl)-2-hydroxymethyl-2,3-dihydro-1,4-benzodioxin-6-carbaldehyde 
• 853786-28-4 (2S,3S)-3-(3',5'-dimethoxy-4'-methoxymethoxyphenyl)-2-hydroxymethyl-2,3-dihydro-1,4-benzodioxin-6-carbaldehyde 
• 853786-37-5 (1'R,2'S)-4-hydroxy-3-[2',3'-epoxy-1'-(3'',5''-dimethoxy-4''-methoxymethoxyphenyl)-propoxy]-benzaldehyde 
• 853786-27-3 (1'S,2'R)-4-hydroxy-3-[2',3'-epoxy-1'-(3'',5''-dimethoxy-4''-methoxymethoxyphenyl)-propoxy]-benzaldehyde 
• 853786-22-8 (1R,2R)-1-(2-Bromo-3,5-dimethoxy-4-methoxymethoxy-phenyl)-propane-1,2,3-triol 
• 853786-21-7 (1R,2R)-1-(3',5'-dimethoxy-4'-methoxymethoxyphenyl)-2,3-dihydroxypropanol 
• 853786-31-9 (1S,2S)-1-(3',5'-dimethoxy-4'-methoxymethoxyphenyl)-2,3-dihydroxypropanol 
• 853786-25-1 (1R,2R)-2,3-epoxy-1-(3',5'-dimethoxy-4'-methoxymethoxyphenyl)propanol 

Relevant articles and documents

Synthesis and in vitro biological evaluation of novel dendrocandin analogue as potential anti-tumor agent

Dendrocandins are characteristic chemical structures of D. officinale and have strong physiological bioactivities. In this study, a dendrocandin analogue (1) has been prepared by total synthesis (9 steps, 12.6% overall yield) in which coupling reaction and Wittig reaction as the key steps. Compound 1 was also evaluated for its anticancer activity in vitro against six human cancer cells (MCF-7, A549, A431, SW480, HepG-2 and HL-60) using MTT assays. Compound 1 showed potent cytotoxicity, with the IC50 value 16.27 ± 0.26 μM. The expression levels of apoptotic proteins indicated that compound 1 can up-regulate the expression of apoptotic proteins, leading to apoptosis. This compound suggested that it’s potential as anticancer agent for further development.