855298-16-7

Basic information

• Product Name: Benzene, 1-[(1E)-2-(phenylsulfonyl)ethenyl]-4-(trifluoromethyl)-
• CAS NO: 855298-16-7
• Molecular Formula: C15H11F3O2S
• Molecular Weight: 312.312
• Mol File: 855298-16-7.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(1E)-2-(phenylsulfonyl)ethenyl]-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(1E)-2-(phenylsulfonyl)ethenyl]-4-(trifluoromethyl)-(855298-16-7)
• EPA Substance Registry System: Benzene, 1-[(1E)-2-(phenylsulfonyl)ethenyl]-4-(trifluoromethyl)-(855298-16-7)

Safety Data

• Hazardous Substances Data: 855298-16-7(Hazardous Substances Data)

Upstream product

• 16642-92-5 4-(trifluoromethyl)cinnamic acid 
• 873-55-2 sodium benzenesulfonate 
• 108-98-5 thiophenol 
• 80-17-1 benzenesufonyl hydrazide 
• 3792-88-9 3-[4-(trifluoromethyl)phenyl]-2-propynoic acid 
• 2062-26-2 3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid 
• 38066-16-9 diethyl [(phenylthio)methyl]phosphonate 
• 5535-48-8 PVS 
• 1384879-87-1 (E)-methyl 3-oxo-3-[2-(4-trifluoromethylstyryl)phenyl]propanoate 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 56069-39-7 diethyl phenylsulfonylmethylphosphonate 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 2991-42-6 4-trifluorophenylsulfonyl chloride 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 1032938-03-6 (E)-2-[4-(trifluoromethyl)phenyl]-1-[tris(trimethylsilyl)silyl]ethene 
• 1189143-63-2 C₁₅H₁₂F₃NS 

Relevant articles and documents

Generation of potent Nrf2 activators via tuning the electrophilicity and steric hindrance of vinyl sulfones for neuroprotection

Oxidative stress is constantly involved in the etiopathogenesis of an ever-widening range of neurodegenerative diseases. As a consequence, effective repression of cellular oxidative stress to a redox homeostatic condition is a promising and feasible strategy to treat, or at least retard the progression of, such disorders. Nrf2, a primary orchestrator of cellular antioxidant response machine, is responsible for detoxifying and compensating for deleterious oxidative stress via transcriptional activation of a diverse array of antioxidant biomolecules. In the framework of our persistent interest in disclosing small molecules that interfere with cellular redox-regulating machinery, we report herein the synthesis, optimization, and biological assessment of 47 vinyl sulfone scaffold-bearing small molecules, most of which exhibit robust neuroprotective effect against H2O2-mediated lesions to PC12 cells. After initial screening, the most potent neuroprotective compounds 9b and 9c with marginal cytotoxicity were selected for the follow-up studies. Our results demonstrate that their neuroprotective effects are attributed to the up-regulation of a panel of antioxidant genes and corresponding gene products. Further mechanistic studies indicate that Nrf2 is indispensable for the cellular performances of 9b and 9c, arising from the fact that silence of Nrf2 gene drastically nullifies their protective action. Taken together, 9b and 9c discovered in this work merit further development as neuroprotective candidates for the treatment of oxidative stress-mediated pathological conditions.

Visible-light-induced decarboxylative sulfonylation of cinnamic acids with sodium sulfinates by using Merrifield resin supported Rose Bengal as a catalyst

A visible-light-induced decarboxylative sulfonylation of cinnamic acids with sodium sulfinates for the synthesis of vinyl sulfones was developed. The reaction proceeded smoothly in the presence of Merrifield resin supported Rose Bengal ammonium salt as a

Electrosynthesis of (E)-Vinyl Sulfones Directly from Cinnamic Acids and Sodium Sulfinates via Decarboxylative Sulfono Functionalization

A variety of (E)-vinyl sulfones were constructed directly from cinnamic acids and sodium sulfinates with high regioselectivity at room temperature by virtue of an electrocatalytic oxidation. A radical intermediate was detected, and the corresponding mecha