856965-68-9Relevant articles and documents
Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
Pfefferkorn, Jeffrey A.,Lou, Jihong,Minich, Martha L.,Filipski, Kevin J.,He, Mingying,Zhou, Ru,Ahmed, Syed,Benbow, John,Perez, Angel-Guzman,Tu, Meihua,Litchfield, John,Sharma, Raman,Metzler, Karen,Bourbonais, Francis,Huang, Cong,Beebe, David A.,Oates, Peter J.
scheme or table, p. 3247 - 3252 (2010/03/03)
A promising area of novel anti-diabetic therapy involves identification of small molecule activators of the glucokinase enzyme to reduce blood glucose and normalize glucose stimulated insulin secretion. Herein, we report the identification and optimizatio
