86061-04-3

Basic information

• Product Name: FMOC-GLU(OTBU)-OPFP
• Synonyms: FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER PENTAFLUOROPHENYL ESTER;FMOC-L-GLU(TBU)-OPFP;FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL-ALPHA-PENTAFLUOROPHENYL DI-ESTER;FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER ALPHA-PENTAFLUOROPHENYL ESTER;FMOC-L-GLUTAMIC ACID 5-TERT-BUTYL 1-(PENTAFLUOROPHENYL) ESTER;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMIC-ACID-GAMMA-T-BUTYL ESTER PENTAFLUORPHENYL ESTER;N-ALPHA-FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER PENTAFLUOROPHENYL ESTER;N-fmoc-gamma-T-butyl-L-glutamic acid*pentafluorop
• CAS NO: 86061-04-3
• Molecular Formula: C₃₀H₂₆F₅NO₆
• Molecular Weight: 591.52
• EINECS: 2017-001-1
• Product Categories: Amino Acids;Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
• Mol File: 86061-04-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 119-120℃
• Boiling Point: 674.2 °C at 760 mmHg
• Flash Point: 361.5 °C
• Appearance: /Solid
• Density: 1.352g/cm³
• Vapor Pressure: 4.89E-18mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C
• PKA: 10.08±0.46(Predicted)
• BRN: 3642680
• CAS DataBase Reference: FMOC-GLU(OTBU)-OPFP(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-GLU(OTBU)-OPFP(86061-04-3)
• EPA Substance Registry System: FMOC-GLU(OTBU)-OPFP(86061-04-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 86061-04-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C30H26F5NO6/c1-30(2,3)42-21(37)13-12-20(28(38)41-27-25(34)23(32)22(31)24(33)26(27)35)36-29(39)40-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,36,39)/t20-/m0/s1

Upstream product

• 2419-56-9 L-glutamic acid 5-tert-butyl ester 
• 88744-04-1 (9-fluorenyl)methyl pentafluorophenyl carbonate 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 71989-18-9 Fmoc-Glu(OtBu)-OH 
• 244633-31-6 pentafluorophenyl 4-nitrobenzenesulfonate 

Downstream Products

• 1228766-30-0 FmocGlu(OtBu)NH(CH₂)4NHZ 
• 1228766-34-4 FmocGlu(OtBu)NH(CH₂)6NHZ 
• 1228766-32-2 FmocGlu(OtBu)NH(CH₂)5NHZ 
• 1334511-47-5 N-(9-fluorenylmethoxycarbonyl)-O⁽⁵⁾-tert-butyl-L-glutamyl-N-ethyl-S-triphenylmethyl-L-cysteine 
• 287174-03-2 (S)-4-({[(2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-hydroxymethyl-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylcarbamoyl]-methyl}-carbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 
• 287174-02-1 (S)-4-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-{[((2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylcarbamoyl)-methyl]-carbamoyl}-butyric acid 
• 287174-01-0 (S)-4-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-{[((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylcarbamoyl)-methyl]-carbamoyl}-butyric acid 
• 287174-00-9 (S)-4-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-{[((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylcarbamoyl)-methyl]-carbamoyl}-butyric acid 
• 287173-99-3 (S)-4-{[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylcarbamoyl)-methyl]-carbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 

Relevant articles and documents

Synthesis of aryl esters of protected amino acids from aryl sulfonates

Aryl esters of Boc- and Fmoc-protected amino acids derived from electron-deficient phenols have been prepared in good yields from aryl 4- nitrobenzenesulfonates in the presence of 1-hydroxy-benzotriazole as catalyst.

Preparation and Applications of Pentafluorophenyl Esters of 9-Fluorenylmethyloxycarbonyl Amino Acids for Peptide Synthesis

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