86317-99-9Relevant articles and documents
Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore
Gonzalez-Padilla, Jazmin E.,Castrejón-Flores, José L.,Franco-Hernández, Marina O.,Gómez-Castro, Carlos Z.,Gómez-Gómez, Yolanda M.,García-Aranda, Mónica I.,García-Báez, Efrén V.,Padilla-Martínez, Itzia I.,Rosales-Hernández, Martha C.
, (2020/03/25)
Being the base of several non-communicable diseases, including cancer, inflammation is a complex process generated by tissue damage or change in the body homeostatic state. Currently, the therapeutic treatment for chronic inflammation related diseases is
A one-pot synthesis of 1, 2 - diaryl benzimidazole and its derivatives
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Paragraph 0204; 0205; 0206; 0207; 0208; 0209; 0210, (2017/08/25)
The invention discloses a one-pot synthesis method of 1,2-diarylbenzimidazole and derivatives thereof and belongs to the technical field of chemical preparation. The synthesis method comprises the following steps: adding o-phenylenediamine, benzaldehyde and halogeno benzene which are raw materials into a pressure bottle of 50mL according to the ratio of 1:1.2:1, adding a metal catalyst, an alkali, a ligand and an organic solvent, stirring at the temperature of 110-130 DEG C for 16-24 hours to synthesize 1,2-diarylbenzimidazole and derivatives thereof, cooling, filtering, extracting, distilling at a reduced pressure, and carrying out chromatographic separation by using a column to obtain purified products. The one-pot synthesis method disclosed by the invention has the advantages of mild reaction condition, simple post-treatment, high product selectivity and wide substrate expansion range, and in addition, the one-pot synthesis method can be used for constructing polyaryl imidazole compounds and derivatives easily and efficiently.
