86561-24-2Relevant articles and documents
Rh-catalyzed asymmetric hydrogenation of α-aryl-β-alkylvinyl esters with chiral ferrocenylphosphine-phosphoramidite ligand
Dong, Chao,Liu, Dao-Sheng,Zhang, Lei,Hu, Xiang-Ping
supporting information, (2021/02/03)
An enantioselective Rh-catalyzed hydrogenation of E/Z mixtures of trisubstituted vinyl esters has been disclosed. With a combination of [Rh(COD)2]BF4 and a structurally fine-tuning chiral ferrocenylphosphine-phosphoramidite ligand as the catalyst, a variety of E/Z mixtures of α-aryl-β-alkylvinyl esters have been successfully hydrogenated in high yields and with good to high enantioselectivities (up to 96% ee). The presence of a small amount of tBuOH proved to be beneficial to improve the hydrogenation outcome.
Acetate compound synthesis method
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Paragraph 0089-0095, (2020/01/03)
The invention provides an acetate compound synthesis method, and belongs to the field of organic synthesis, wherein the synthesis method has advantages of simple reaction system, no requirement of additional metal catalysts, no requirement of heating, high reaction and efficient synthesis of acetate compounds. According to the technical scheme, the preparation method comprises: respectively addinga styrene compound, an iodoalkyl compound and sodium acetate into a reactor, and carrying out an irradiation reaction for 2-10 h at a room temperature of 20-25 DEG C under a 10 W white daylight lampunder the actions of DDQ and ethanol; and after the reaction is finished, carrying out column chromatography separation to obtain the acetate compound. The method of the invention can be used in synthesis experiments of acetate compounds.
Expanding substrate scope of lipase-catalyzed transesterification by the utilization of liquid carbon dioxide
Hoang, Hai Nam,Matsuda, Tomoko
, p. 7229 - 7234 (2016/10/26)
Secondary alcohols having bulky substituents on both sides of the chiral center are often poor substrates for most lipases. Here we reported that substrate scopes of two of the most used lipases, Candida antarctica lipase B and Burkholderia cepacia lipase, were found to be expanded toward more bulky secondary alcohols such as 1-phenyl-1-dodecanol and 2-methyl-1-phenyl-1-propanol by simply using them in liquid carbon dioxide as a solvent. The effects of solvents, reaction pressure, and pre-treatment of the enzyme with liquid CO2on this acceleration phenomenon were also studied.