868612-83-3 Usage
Description
IN-1130 is a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, which has demonstrated potential in the prevention and treatment of renal fibrosis.
Uses
Used in Pharmaceutical Industry:
IN-1130 is used as a therapeutic agent for the prevention and treatment of renal fibrosis. In a study involving a rat unilateral ureteral obstruction model, IN-1130 showed effectiveness in addressing this condition. This suggests its potential use in managing kidney diseases and improving patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 868612-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,6,1 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 868612-83:
(8*8)+(7*6)+(6*8)+(5*6)+(4*1)+(3*2)+(2*8)+(1*3)=213
213 % 10 = 3
So 868612-83-3 is a valid CAS Registry Number.
868612-83-3Relevant articles and documents
Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors
An, Young Jae,Cha, Geunyoung,Choi, Joon Hun,Dewang, Purushottam M.,Kim, Dae-Kee,Lee, Hwa Jeong,Park, Hyun-Ju,Park, Myoung-Soon,Park, So-Jung
, p. 702 - 712 (2020/03/23)
A series of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles, 7a–c, 11a–h, and 16a–h has been synthesised and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Incorporation of a quinoxal
2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
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Page/Page column 10-11, (2008/06/13)
Compounds of the formula: wherein R1, R2, R3, A1 and A2 are as defined herein, which are used advantageously in inhibiting the TGF-β and/or activin signaling pathway in mammals.
