356560-90-2

Basic information

• Product Name: 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone
• Synonyms: 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone;Ethanone, 2-(6-Methyl-2-pyridinyl)-1-(6-quinoxalinyl)-;2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone-4
• CAS NO: 356560-90-2
• Molecular Formula: C₁₆H₁₃N₃O
• Molecular Weight: 263.29392
• Mol File: 356560-90-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-140 °C
• Boiling Point: 443.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• PKA: 4.62±0.12(Predicted)
• CAS DataBase Reference: 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone(356560-90-2)
• EPA Substance Registry System: 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone(356560-90-2)

Safety Data

• Hazardous Substances Data: 356560-90-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone" is a ketone derivative that consists of a pyridine ring substituted with a methyl group and a quinoxaline ring attached to an ethanone group. 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone may have potential applications in the fields of organic synthesis, medicinal chemistry, and material science. Its unique structure and functional groups could make it suitable for use in the development of pharmaceuticals, agrochemicals, and other specialty chemicals. Further research and testing may be necessary to fully understand the properties and potential uses of this compound.

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 258503-93-4 quinoxaline-6-carbonyl chloride 

Downstream Products

• 364050-21-5 1-(6-methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione 
• 868612-83-3 IN-1130 
• 868612-72-0 4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile 
• 442517-38-6 2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazole 

Relevant articles and documents

Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles (15a-l) have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 4-[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]b enzenesulfonamide (15b) and 4-[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]be nzenesulfonamide (15c) showed more than 90% inhibition at 0.5 μM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct, but inhibited p38α MAP kinase activity only 11 and 8% at a concentration of 10 μM, respectively.

Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 4(5)-(6-alkylpyridin-2-yl)imidazoles 13a-p, 17a, and 17b have been synthesized and evaluated for ALK5 inhibitory activity in an enzyme assay and in cell-based luciferase reporter assays. The quinoxalinyl analogue 13e inhibited ALK5 phosphoryla