868635-67-0Relevant articles and documents
Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist
Okumura, Yoshiyuki,Yamagishi, Tatsuya,Nukui, Seiji,Nakao, Kazunari
, p. 1186 - 1192 (2017/06/21)
Starting from acylsufonamide HTS hit 2, a novel series of para-N-acylaminomethylbenzoic acids was identified and developed as selective prostaglandin EP4 receptor antagonists. Structural modifications on lead compound 4a were explored with the aim of impr