874651-73-7Relevant articles and documents
Catalytic asymmetric total synthesis of the muscarinic receptor antagonist (R)-tolterodine
Hedberg, Christian,Andersson, Pher G.
, p. 662 - 666 (2005)
A convenient and high yielding method for the preparation of (R)-tolterodine, utilizing a catalytic asymmetric Me-CBS reduction was developed. Highly enantioenriched (A)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one (94% ee) was recrystallized to yield practically enantiopure material (ee >99%) and converted to (R)-tolterodine in a four-step procedure. The configuration of the crucial stereocenter was preserved during the synthesis and the obtained product was identified by chiral HPLC to be the (R)-tolterodine enantiomer.