876162-62-8

Basic information

• Product Name: methyl 2-(hydroxy)formanilide-4-carboxylate
• Synonyms: methyl 2-(hydroxy)formanilide-4-carboxylate
• CAS NO: 876162-62-8
• Molecular Weight: 195.175
• Mol File: 876162-62-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-(hydroxy)formanilide-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(hydroxy)formanilide-4-carboxylate(876162-62-8)
• EPA Substance Registry System: methyl 2-(hydroxy)formanilide-4-carboxylate(876162-62-8)

Safety Data

• Hazardous Substances Data: 876162-62-8(Hazardous Substances Data)

Upstream product

• 2374-03-0 4-aminosalicylic acid 
• 67-56-1 methanol 
• 64-18-6 formic acid 
• 63435-16-5 3-hydroxy-4-aminobenzoic acid methyl ester 

Relevant articles and documents

Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors

Fe(II)/α-ketoglutarate-dependent lysine demethylases (KDMs) are attractive drug targets for several diseases including cancer. In this study, we designed and screened ortho-substituted anilides that are expected to function as Fe(II) chelators, and identified ortho-hydroxy anilide as a novel scaffold for KDM5A inhibitors. Treatment of human lung cancer A549 cells with a prodrug form of 4-carboxy-2-hydroxy-formanilide (9c) increased trimethylated lysine 4 on histone H3 level, suggesting KDM5 inhibition in the cells.