877264-73-8

Basic information

• Product Name: 1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-diMethylethyl ester
• Synonyms: 1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-diMethylethyl ester;5-Acetyl-indazole-1-carboxylic acid tert-butyl ester;tert-Butyl 5-acetyl-1H-indazole-1-carboxylate
• CAS NO: 877264-73-8
• Molecular Formula: C₁₄H₁₆N₂O₃
• Molecular Weight: 260.28844
• Mol File: 877264-73-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-diMethylethyl ester(877264-73-8)
• EPA Substance Registry System: 1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-diMethylethyl ester(877264-73-8)

Safety Data

• Hazardous Substances Data: 877264-73-8(Hazardous Substances Data)

Usage

General Description

"1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-dimethylethyl ester" is a chemical compound that belongs to the class of organic compounds known as indazoles, which are aromatic compounds containing a benzene fused to an azole ring. Being a carboxylic acid derivative, it is an ester resulting from the replacement of the acidic hydrogen of the carboxylic acid by an organic group - in this case, the 1,1-dimethylethyl group. The presence of the 5-acetyl group indicates that an acetyl group is attached to the fifth carbon in the molecule's base structure. Although its specific uses or applications are not widely reported, substances in this class frequently contribute to the synthesis of various pharmaceuticals, material sciences, and other chemical researches.

Upstream product

• 1001907-23-8 tert-butyl 5-iodo-1H-indazole-1-carboxylate 
• 111-34-2 -butyl vinyl ether 
• 61700-61-6 1H-indazole-5-carboxylic acid 
• 53857-57-1 5-bromo-1H-indazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1093306-90-1 N-methoxy-N-methyl-1H-indazole-5-carboxamide 
• 1001906-63-3 1-(1H-indazole-5-yl)-ethanone 
• 651780-02-8 tert-butyl 5-bromo-1H-indazole-1-carboxylate 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 

Downstream Products

• 1001906-63-3 1-(1H-indazole-5-yl)-ethanone 
• 1093302-85-2 4-(1H-indazol-5-yl)-N-phenyl-1,3-thiazol-2-amine 
• 1093302-88-5 N-benzyl-4-(1H-indazol-5-yl)-1,3-thiazol-2-amine 
• 1093302-90-9 4-(1H-indazol-5-yl)-N-(2-phenylethyl)-1,3-thiazol-2-amine 
• 877264-74-9 tert-butyl 5-(2-bromoacetyl)-1H-indazole-1-carboxylate 

Relevant articles and documents

Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions

We report the synthesis and biological evaluation of 5-substituted indazoles as kinase inhibitors. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing heterocycle forming and multicomponent reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for Gsk3β, Rock2, and Egfr.

5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.