88499-85-8

Basic information

• Product Name: 6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL
• Synonyms: 6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL;Nsc150955;1,5,6,7-tetrahydro-2H-cyclopenta[b]pyridin-2-one(SALTDATA: FREE);6,7-dihydro-1H-cyclopenta[b]pyridin-2(5H)-one;1,5,6,7-Tetrahydro-2H-cyclopenta[b]pyridin-2-one;1H,5H,6H,7H-Cyclopenta[b]pyridin-2-one;5H,6H,7H-cyclopenta[b]pyridin-2-ol;2H-Cyclopenta[b]pyridin-2-one, 1,5,6,7-tetrahydro-
• CAS NO: 88499-85-8
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.1632
• Mol File: 88499-85-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 180-181 °C(Solv: water (7732-18-5))
• Boiling Point: 402.7 °C at 760 mmHg
• Flash Point: 234.1 °C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 1.07E-06mmHg at 25°C
• Refractive Index: 1.579
• PKA: 13.05±0.20(Predicted)
• CAS DataBase Reference: 6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL(88499-85-8)
• EPA Substance Registry System: 6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL(88499-85-8)

Safety Data

• Hazardous Substances Data: 88499-85-8(Hazardous Substances Data)

Usage

General Description

6,7-Dihydro-5H-cyclopenta[b]pyridin-2-ol, also known as 6,7-dihydro-2H-pyrido[3,2,1-ij]quinolin-5-ol, is a chemical compound that belongs to the class of cyclopenta[b]pyridine derivatives. It is a heterocyclic compound with a five-membered ring fused to a six-membered ring. 6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL is not commonly found in nature, but it can be synthesized in the laboratory for various research and industrial purposes. It has potential applications in pharmaceuticals, agrochemicals, and material science due to its unique structural and chemical properties. Additionally, it may serve as a building block for the synthesis of other complex organic compounds.

InChI:InChI=1/C8H9NO/c10-8-5-4-6-2-1-3-7(6)9-8/h4-5H,1-3H2,(H,9,10)

Upstream product

• 115122-63-9 2-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxylic acid 
• 7647-01-0 hydrogenchloride 
• 856152-69-7 7a-hydroxy-2-oxo-2,3,5,6,7,7a-hexahydro-1H-[1]pyrindine-3-carbonitrile 
• 120-92-3 cyclopentanone 
• 1590409-65-6 ethyl 1-(3-amino-3-oxoprop-1-enyl)-2-oxocyclopentanecarboxylate 
• 4594-77-8 2-oxocyclopentanepropiononitrile 
• 1199941-88-2 methyl 1-(3-amino-3-oxoprop-1-enyl)-2-oxocyclopentanecarboxylate 
• 108106-97-4 2-oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine-3-carbonitrile 
• 922-67-8 propynoic acid methyl ester 
• 88499-81-4 methyl-6 (pentyn-4'-yl)-2 pyrimidone-4 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 930-91-6 2-hydroxymethylenecyclopentanone 
• 5650-69-1 6,7-dihydrocyclopenta[b]pyran-2(5H)-one 
• 631-61-8 ammonium acetate 

Downstream Products

• 117890-55-8 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine 
• 1590402-75-7 C₁₄H₁₃NO 
• 247185-52-0 (R)-7-hydroxy-2-phenyl-6,7-dihydro-5H-<1>pyridine 
• 1256823-72-9 2-bromo-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one 
• 1140240-18-1 2-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine 
• 158331-18-1 3-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine 
• 858343-04-1 N-[4-(hydroxy-m-tolyl-methyl)-2-methoxy-6,7-dihydro-5H-[1]pyrindin-3-yl]-2,2-dimethyl-propionamide 
• 858343-06-3 N-[2-methoxy-4-(3-methyl-benzoyl)-6,7-dihydro-5H-[1]pyrindin-3-yl]-2,2-dimethyl-propionamide 
• 248248-32-0 3-amino-4-(3-methyl-benzoyl)-1,5,6,7-tetrahydro-[1]pyrindin-2-one 

Relevant articles and documents

Method for preparing chiral nitrogen-phosphorus ligand L-8 containing pyridocyclopentane

The invention discloses a method for preparing chiral nitrogen-phosphorus ligand L-8 containing pyridocyclopentane, and belongs to the technical field of medical intermediate chiral ligands. The chiral nitrogen-phosphorus L-8 ligand is prepared from cyclopentanone through the steps of addition, cyclization, chlorination, asymmetric boronation, oxidation, coupling, esterification and the like in sequence, large-scale preparation is relatively easy to achieve through the route, and the defect that in a traditional route, the yield is low in the first step of ring closing reaction and chiral alcohol preparation is overcome, and by selecting a proper chiral ligand, and combining with butyl lithium, asymmetric synthesis of chiral alcohol is realized, and a chiral separation column mode adoptedin literature is avoided.

SUBSTITUTED L,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

Ligand-Enabled β-C–H Arylation of α-Amino Acids Without Installing Exogenous Directing Groups

Herein we report acid-directed β-C(sp3)-H arylation of α-amino acids enabled by pyridine-type ligands. This reaction does not require the installation of an exogenous directing group, is scalable, and enables the preparation of Fmoc-protected unnatural amino acids in three steps. The pyridine-type ligands are crucial for the development of this new C(sp3)-H arylation.