886469-23-4 Usage
Description
PEG9-Tos is a PEG linker that contains a hydroxyl group with a tosyl group. It features a hydrophilic PEG spacer, which enhances solubility in aqueous media, and the hydroxyl group allows for further derivatization or replacement with other reactive functional groups. The tosyl group acts as an excellent leaving group for nucleophilic substitution reactions.
Uses
Used in Organic Synthesis:
PEG9-Tos is used as a versatile building block for organic synthesis, particularly in the creation of biocompatible polymers and other complex organic molecules. Its hydrophilic PEG spacer and hydroxyl group facilitate the attachment of various functional groups, making it a valuable component in the synthesis of pharmaceuticals, biomaterials, and other specialty chemicals.
Used in Drug Delivery Systems:
In the pharmaceutical industry, PEG9-Tos is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG spacer can be used to attach drug molecules or other targeting moieties, enhancing the overall performance of the drug delivery system.
Used in Bioconjugation:
PEG9-Tos is utilized as a linker in bioconjugation processes, where it serves to covalently attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The hydroxyl group and tosyl leaving group enable efficient conjugation, while the PEG spacer provides steric stabilization and reduces immunogenicity or non-specific interactions.
Used in Surface Modification:
In materials science, PEG9-Tos is employed for surface modification of various substrates, including nanoparticles, polymers, and other surfaces. The PEG spacer and hydroxyl group allow for the attachment of PEGylated layers, which can improve the biocompatibility, reduce protein adsorption, and enhance the stability of the modified surfaces.
Used in Cosmetics and Personal Care:
In the cosmetics and personal care industry, PEG9-Tos is used as an ingredient to improve the solubility and stability of active ingredients, as well as to provide moisturizing and conditioning effects. The hydrophilic nature of the PEG spacer and the ability to derivatize the hydroxyl group make it suitable for a wide range of cosmetic formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 886469-23-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,4,6 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 886469-23:
(8*8)+(7*8)+(6*6)+(5*4)+(4*6)+(3*9)+(2*2)+(1*3)=234
234 % 10 = 4
So 886469-23-4 is a valid CAS Registry Number.
886469-23-4Relevant articles and documents
Supramolecular compound nano-carrier as well as preparation method and application thereof
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, (2021/08/14)
The invention discloses a supramolecular compound nano-carrier as well as a preparation method and application thereof, and relates to the technical field of polymer chemistry and biological detection engineering. According to the supramolecular compound nano-carrier disclosed by the invention, a two-dimensional nanosheet supramolecular structure system generated by self-assembly is driven by an anion induction effect, and a supramolecular compound nano-carrier is of a single-layer nanosheet supramolecular structure constructed by a highly-oriented one-dimensional nanorod. A hydrophobic perylene group part is used as a skeleton part for constructing the highly-oriented one-dimensional nanorod, and the charge density of a single-layer nanosheet can be regulated and controlled. The surface of the water-soluble multivalent hydrophilic part can be loaded with DNAzyme deoxyribozyme for specific detection of heavy metal ions through electrostatic interaction, and the water-soluble multivalent supramolecular compound nano sensor is constructed. Based on a fluorescence change mechanism caused by specific cutting of heavy metal ions, The fluorescence detection of the heavy metal ions in food and biological tissues is realized, and the detection effect of the heavy metal ions is greatly enhanced.
MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS
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Page/Page column 474; 475, (2016/06/06)
The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Synthesis of Patent Blue derivatized hydrophilic dendrons dedicated to sentinel node detection in breast cancer
Kueny-Stotz, Marie,Mamlouk-Chaouachi, Hind,Felder-Flesch, Delphine
scheme or table, p. 2906 - 2909 (2011/06/21)
In the last decade, methods for the precise localization of sentinel lymph node (SLN) have drawn tremendous attention by oncology surgeons and researchers in the field of medical diagnosis. The accurate identification and characterization of lymph nodes by imaging has important therapeutic and prognostic significance in patients with newly diagnosed cancers. The SLN is the first lymph node that receives lymphatic drainage from the site of a primary tumor. Two biocompatible dendronized phosphonates, one bearing a Patent Blue (PB VF) dye at its periphery, where synthesized. Indeed, such a blue dye is currently injected to label the lymph node system for its per-operative detection. Therefore, developing chemistry of Patent Blue VF to optimize early diagnosis is of great current interest.
