886755-45-9

Basic information

• Product Name: 3-(4-ethoxycarbonylphenyl)indazole
• Synonyms: 3-(4-ethoxycarbonylphenyl)indazole
• CAS NO: 886755-45-9
• Molecular Weight: 266.299
• Mol File: 886755-45-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(4-ethoxycarbonylphenyl)indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-ethoxycarbonylphenyl)indazole(886755-45-9)
• EPA Substance Registry System: 3-(4-ethoxycarbonylphenyl)indazole(886755-45-9)

Safety Data

• Hazardous Substances Data: 886755-45-9(Hazardous Substances Data)

Upstream product

• 1018788-84-5 4-(1H-indazol-3-yl)benzoic acid 
• 64-17-5 ethanol 
• 1001084-41-8 3-(4-methoxycarbonylphenyl)indazole 
• 6630-33-7 ortho-bromobenzaldehyde 
• 106-38-7 para-bromotoluene 
• 59142-66-4 (2-bromophenyl)(p-tolyl)methanol 
• 67104-64-7 2-bromophenyl(4-methylphenyl)methanone 
• 746651-78-5 ethyl 4-(2-bromobenzoyl)benzoate 

Downstream Products

• 1018789-01-9 C₁₉H₂₀N₂O₂ 
• 1018789-02-0 C₂₀H₂₂N₂O₂ 
• 1018788-96-9 C₂₂H₁₉N₃O₂ 
• 1018788-94-7 C₂₂H₁₉N₃O₂ 
• 886755-47-1 N-2-benzyl-3-(4-ethoxycarbonylphenyl)indazole 
• 170632-41-4 1-benzyl-3-(4'-ethoxycarbonylphenyl)indazole 
• 1001084-49-6 N-1-(4-chlorobenzyl)-3-(4-ethoxycarbonylphenyl)indazole 
• 886755-50-6 ethyl 4-[1-(2-fluorobenzyl)-1H-indazol-3-yl]benzoate 
• 1001084-45-2 N-1-(2-chlorobenzyl)-3-(4-ethoxycarbonylphenyl)indazole 
• 1018788-91-4 C₂₄H₂₂N₂O₃ 
• 1018788-99-2 C₁₈H₁₈N₂O₂ 
• 1018789-00-8 C₁₉H₂₀N₂O₂ 
• 1018788-93-6 C₂₄H₂₂N₂O₃ 
• 1018788-92-5 C₂₄H₂₂N₂O₃ 

Relevant articles and documents

Preparation method of indazole and application of indazole in medicine synthesis

The invention belongs to the field of chemicals, and relates to a preparation method of indazole and an application of the indazole in medicine synthesis. The invention discloses a preparation method of indazole and an application of the indazole in synthesizing 1H-indazole-3-carboxylic acid, lonidamine, a compound 8, a compound 9, a compound 10, axitinib, YD-3, YC-1 and similar substances thereof.

Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives

Previously, ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) was identified by us as the first non-peptide protease-activated receptor 4 (PAR4) antagonist. To continue on our development of novel anti-PAR4 agents, YD-3 was used as a lead compound and a series of its derivatives were synthesized and evaluated for their selective anti-PAR4 activity. Through structure-activity relationship (SAR) study, we identified the important functional groups contributing to anti-PAR4 activity, and these functional groups were kept intact during subsequent structural modification. Several new compounds with anti-PAR4 activity comparable to YD-3 were identified. Among them, ethyl 4-[1-(3-chlorobenzyl)-1H-indazol-3-yl]benzoate (33) showed the most potent inhibitory effect on PAR4-mediated platelet aggregation, ATP release, and P-selectin expression. On the other hand, ethyl 4-(1-phenyl-1H-indazol-3-yl)benzoate (83) exhibited dual inhibitory effects on PAR4 and thromboxane formation from arachidonic acid. The above findings can be used as guidelines for development of novel antiplatelet drug candidates.

Synthesis of N2 - (substituted arylmethyl) -3- (substituted phenyl) indazoles as novel anti-angiogenic agents

Novel compounds of 2-(substituted arylmethyl)-3-(substituted phenyl)-2H-indazoles and 1-(substituted arylmethyl)-3-(substituted phenyl)-1H-indazoles are synthesized, and useful as anti-angiogenic agents.