888-71-1

Basic information

• Product Name: 3,5-diphenyl-1,2,4-oxadiazole
• Synonyms: 3,5-diphenyl-1,2,4-oxadiazole;Diphenyl-1,2,4-oxadiazole
• CAS NO: 888-71-1
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.25
• Mol File: 888-71-1.mol
• Article Data: 93

Chemical Properties

• Melting Point: 109°C
• Boiling Point: 363.42°C (rough estimate)
• Flash Point: 182.7°C
• Appearance: /
• Density: 1.1400 (rough estimate)
• Vapor Pressure: 1.32E-05mmHg at 25°C
• Refractive Index: 1.5910 (estimate)
• CAS DataBase Reference: 3,5-diphenyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-diphenyl-1,2,4-oxadiazole(888-71-1)
• EPA Substance Registry System: 3,5-diphenyl-1,2,4-oxadiazole(888-71-1)

Safety Data

• Hazardous Substances Data: 888-71-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H10N2O/c1-3-7-11(8-4-1)13-15-14(17-16-13)12-9-5-2-6-10-12/h1-10H

Upstream product

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• 19768-02-6 3,4-diphenylfurazan 
• 62-53-3 aniline 
• 64-19-7 acetic acid 
• 10302-94-0 (Z)-2-chloro-2-butenedioic acid, diethyl ester 
• 141-52-6 sodium ethanolate 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 65-85-0 benzoic acid 
• 1670-14-0 benzamidine monohydrochloride 
• 698-16-8 benzohydroximoyl chloride 
• 31698-83-6 3,9b-diphenyl-8,9,9a,9b-tetrahydro-5aH-benzo[4,5]isoxazolo[2,3-d][1,2,4]oxadiazole 
• 98-07-7 Benzotrichlorid 
• 873-67-6 benzonitrile oxide 
• 69305-79-9 N,N-diethylamino benzamidoxime 

Downstream Products

• 7664-41-7 ammonia 
• 65-85-0 benzoic acid 
• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 1821-33-6 N-phenyl-N'-benzoylurea 
• 948027-85-8 (Z)-N-[(2,2,3,3-tetramethylaziridine-1-yl)(phenyl)methylidene]benzamide 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 100-47-0 benzonitrile 
• 4115-15-5 3,5-diphenyl-[1,2,4]thiadiazole 
• 16776-73-1 N-benzoyl-benzamidine 
• 17467-15-1 2-amino-4-phenyl-1,3,5-thiadiazole 
• 34985-93-8 1-amino-3,5-diphenyl-1,2,4-triazole 
• 64017-21-6 3,5-diphenyl-1-methyl-1H-1,2,4-triazole 
• 66130-15-2 N-(methylaminocarbonyl)-N'-phenylbenzamidine 
• 2039-06-7 3,5-diphenyl-1,2,4-triazole 

Relevant articles and documents

A Selective Synthesis of 3,5-Diphenyl-1,2,4-Oxadiazole by a Reaction of Benzylcobaloxime with Alkyl Nitrite

Benzyl ligand of Benzylbis(dimethylglyoximato)pyridine cobalt complexe was selectively converted to 3,5-diphenyl-1,2,4-oxadiazole by a reaction with alkyl nitrite under irradiation of visible light.The reaction proceeds via an in situ formation of an oxim

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Synthesis method of 3, 5-disubstituted 1, 2, 4-oxadiazole

The invention relates to a novel synthetic method for synthesizing 3, 5-disubstituted-1, 2, 4-oxadiazole, in particular to a synthetic method of 3, 5-disubstituted-1, 2, 4-oxadiazole. The method disclosed by the invention has the characteristics that the reaction is carried out at room temperature, the 1, 2, 4-oxadiazole is synthesized at high yield by a one-pot method, and a final product does not need to be subjected to column chromatography. The 3, 5-disubstituted-1, 2, 4-oxadiazole synthesized by the invention can be used in the field of medical treatment.