891183-50-9

Basic information

• Product Name: (S)-4,4-DIMETHYL-PYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: (S)-4,4-DIMETHYL-PYRROLIDINE-2-CARBOXYLIC ACID;4,4-Dimethyl-pyrrolidine-2-carboxylic acid ethyl ester;4,4-DiMethyl-L-proline HCl;4,4-Dimethyl-L-proline;L-Proline, 4,4-diMethyl-;4,4-Dimethyl-L-proline hydrochloride;(2S)-4,4-Dimethylpyrrolidine-2-carboxylic acid
• CAS NO: 891183-50-9
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.19
• Mol File: 891183-50-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 210.2 °C
• Boiling Point: 246℃
• Flash Point: 103℃
• Appearance: /
• Density: 1.057
• Storage Temp.: 2-8°C
• PKA: 2.37±0.40(Predicted)
• CAS DataBase Reference: (S)-4,4-DIMETHYL-PYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4,4-DIMETHYL-PYRROLIDINE-2-CARBOXYLIC ACID(891183-50-9)
• EPA Substance Registry System: (S)-4,4-DIMETHYL-PYRROLIDINE-2-CARBOXYLIC ACID(891183-50-9)

Safety Data

• Hazardous Substances Data: 891183-50-9(Hazardous Substances Data)

Usage

General Description

(S)-4,4-Dimethyl-pyrrolidine-2-carboxylic acid is a chemical compound that belongs to the class of pyrrolidine carboxylic acids. It is a chiral compound with two enantiomers, (S)- and (R)- forms. (S)-4,4-Dimethyl-pyrrolidine-2-carboxylic acid is primarily used as a building block in the synthesis of pharmaceuticals and other organic compounds. It can also be used as a chiral auxiliary in asymmetric synthesis. Additionally, it has potential applications in the development of new materials and chemical processes. Overall, (S)-4,4-Dimethyl-pyrrolidine-2-carboxylic acid plays an important role in organic chemistry and has various applications in the pharmaceutical and chemical industries.

Upstream product

• 57224-50-7 (S)-2-Amino-4,4-dimethyl-pentanoic acid 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 1001353-86-1 (S)-4,4-dimethylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 212890-85-2 (S)-(+)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol 
• 156088-45-8 (5S)-1-aza-2,2-dimethyl-7,7-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane 
• 156088-46-9 (5S)-3,3-dimethyl-5-hydroxymethylpyrrolidin-2-one 
• 99208-71-6 (5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane 
• 443984-28-9 (S)-(N-benzyloxycarbonyl)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol 
• 1001353-87-2 (2S)-1-(tert-butoxycarbonyl)-4,4-dimethylpyrrolidine-2-carboxylic acid 
• 63624-44-2 3-chloro-5,5-dimethyl-piperidin-2-one 

Relevant articles and documents

Remote C-H Hydroxylation by an α-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs

Selective C-H functionalization at distal positions remains a highly challenging problem in organic synthesis. Though Nature has evolved a myriad of enzymes capable of such feat, their synthetic utility has largely been overlooked. Here, we functionally characterize an α-ketoglutarate-dependent dioxygenase (Fe/αKG) that selectively hydroxylates the ? position of various aliphatic amino acids. Kinetic analysis and substrate profiling of the enzyme show superior catalytic efficiency and substrate promiscuity relative to other Fe/αKGs that catalyze similar reactions. We demonstrate the practical utility of this transformation in the concise syntheses of a rare alkaloid, manzacidin C, and densely substituted amino acid derivatives with remarkable step efficiency. This work provides a blueprint for future applications of Fe/αKG hydroxylation in complex molecule synthesis and the development of powerful synthetic paradigms centered on enzymatic C-H functionalization logic.

PYRROLOTRIAZINE KINASE INHIBITORS

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.