892871-92-0

Basic information

• Product Name: C₁₈H₁₈O₂
• Synonyms: C₁₈H₁₈O₂
• CAS NO: 892871-92-0
• Molecular Weight: 266.34
• Mol File: 892871-92-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₈O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₈O₂(892871-92-0)
• EPA Substance Registry System: C₁₈H₁₈O₂(892871-92-0)

Safety Data

• Hazardous Substances Data: 892871-92-0(Hazardous Substances Data)

Upstream product

• 114590-73-7 1-(3-isopropoxyphenyl)ethanone 
• 100-52-7 benzaldehyde 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 3033-92-9 1-(3-hydroxyphenyl)-3-phenyl-2-propen-1-one 

Relevant articles and documents

Toxicity assessments of Chalcone and some Synthetic Chalcone Analogues in a Zebrafish model

The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a-d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.