89640-51-7

Basic information

• Product Name: 3-IODO-4-HYDROXYANILINE
• Synonyms: 4-HYDROXY-3-IODOANILINE;3-IODO-4-HYDROXYANILINE;4-Amino-2-iodophenol >=95.0% (HPLC)
• CAS NO: 89640-51-7
• Molecular Formula: C₆H₆INO
• Molecular Weight: 235.02
• Mol File: 89640-51-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 110-120°C ((subl.)) (lit.)
• Boiling Point: 286.982 °C at 760 mmHg
• Flash Point: 127.362 °C
• Appearance: /
• Density: 2.094 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.74
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• BRN: 2716290
• CAS DataBase Reference: 3-IODO-4-HYDROXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-4-HYDROXYANILINE(89640-51-7)
• EPA Substance Registry System: 3-IODO-4-HYDROXYANILINE(89640-51-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 89640-51-7(Hazardous Substances Data)

Usage

General Description

3-IODO-4-HYDROXYANILINE is a chemical compound with the molecular formula C6H6INO. It is an important intermediate in the synthesis of pharmaceuticals and dyes. This chemical is used in the manufacturing of various drugs, including anti-inflammatory and anti-bacterial agents. It is also utilized in the production of dyes and pigments for the textile and paper industry. Additionally, 3-IODO-4-HYDROXYANILINE is a potential mutagen and can cause irritation to the skin, eyes, and respiratory system if not handled properly. Due to its versatile applications, this compound plays a crucial role in the pharmaceutical and chemical industries.

InChI:InChI=1/C6H6INO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H,8H2

Upstream product

• 89487-91-2 2-iodo-4-nitrophenol 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 305-85-1 2,6-diiodo-4-nitrophenol 
• 533-58-4 2-Iodophenol 
• 645-00-1 m-iodonitrobenzene 

Downstream Products

• 186519-75-5 2-iodo-4-(6-methyl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenol hydrochloride 
• 1058717-64-8 (E)-4-[(3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl]-N-(4-hydroxy-3-iodophenyl)benzamide 
• 141626-36-0 dronedarone 
• 111221-29-5 4-acetamido-2-iodophenyl acetate 
• 3958-83-6 2-iodocyclohexa-2,5-diene-1,4-dione 
• 134757-46-3 C₂₁H₂₁IN₄O₆ 

Relevant articles and documents

Structure activity relationships for mitomycin C and mitomycin A analogues

A set of 30 mitomycin C and mitomycin A analogues, including five new compounds, was screened against three different solid human tumor cell lines using the MTT tetrazolium dye assay. A statistically significant correlation among antitumor activity, quinone reduction potential (E( 1/2 ), and the logarithm of the partition coefficient (log P) was obtained, with the most easily reduced and the most lipophilic compounds being the most potent. When these analogues were separated into mitomycin C and mitomycin A subsets, the former gave a correlation only with E( 1/2 ), whereas the latter (which differ little in their E( 1/2 ) values) gave a correlation only with log P. These correlations are in contrast to those made in the P388 leukemia assay in mice wherein the most active mitomycin C and mitomycin A analogues were the most hydrophilic ones. When the same compounds were tested against P388 leukemia cells in the MTT assay, the results were the same as those of the solid tumor assays. Thus, the substantial differences in relative potencies of mitomycins are related not to the kind of tumor cell, but to the type of assay performed, cell culture versus whole animal. No correlation was found between antitumor potency in the cell culture systems and calculated relative DNA binding strengths, probably because the limiting factors in antitumor potency of mitomycins appear to be tumor cell uptake (log P) and/or bioreductive activation (E( 1/2 ).

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.

Enhanced color deposition for hair with sequestering agents

Hair coloring compositions which comprise: (A) non-nitrogenous chelating agents from the group consisting of polyphosphate; phosphonates; hydroxycarboxylates; polyacrylates; zeolite; and mixtures thereof; (B) an oxidative dye primary intermediate; and (C) an oxidative dye coupler; (D) and water are described. The present invention also relates to a method for coloring hair which comprises contacting said hair with a hair coloring composition as described above.