90123-25-4Relevant articles and documents
Synthesis of rac-hippospongic acid A and revision of the structure
Tokumasu, Munetaka,Ando, Hiroshi,Hiraga, Yoshikazu,Kojima, Satoshi,Ohkata, Katsuo
, p. 489 - 496 (1999)
rac-Hippospongic acid A of the reported structure 1 and the revised structure 2 were synthesized. The synthetic strategy of these compounds consists of homologation of (2E,6E,10E)-geranylgeraniol and (2E,6E)-farnesol, respectively, Wadsworth-Emmons reaction, and cyclization to form the tetrahydropyran ring bearing an α-methylene group on the carboxylic moiety. Spectral comparisons of the synthetic compounds 1,2 and the natural product suggested that hippospongic acid A bears the structure of 2.