901373-59-9

Basic information

• Product Name: 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide
• Synonyms: 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide
• CAS NO: 901373-59-9
• Molecular Weight: 320.329
• Mol File: 901373-59-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide(901373-59-9)
• EPA Substance Registry System: 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide(901373-59-9)

Safety Data

• Hazardous Substances Data: 901373-59-9(Hazardous Substances Data)

Upstream product

• 723-46-6 sulfamethoxazole 
• 36140-83-7 1-cyanoacetyl-3,5-dimethylpyrazole 

Downstream Products

• 1627962-88-2 4‐(6‐amino‐3,5‐dicyano‐2‐oxo‐4‐phenylpyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide 
• 1627962-89-3 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide 
• 141501-94-2 N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-2-oxo-2H-chromene-3-carboxamide 
• 1627962-98-4 4-[(5-amino-1H-pyrazol-3-yl)amino]-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-00-1 4-({5-amino-4-[phenyldiazenyl]-1H-pyrazol-3-yl}amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-02-3 4-({5-amino-4-[(4-methoxyphenyl)diazenyl]-1H-pyrazol-3-yl}amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-04-5 4-({5-amino-4-[(4-chlorophenyl)diazenyl]-1H-pyrazol-3-yl}amino)-N-(5-methylisoxazol-3-yl)benzensulfonamide 
• 1627963-05-6 4-(6-cyano-3,5-dioxo-2-phenyl-2,5-dihydro-1,2,4-triazin-4(3H)-yl)-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-06-7 4-[6-cyano-2-(4-methoxyphenyl)-3,5-dioxo-2,5-dihydro-1,2,4-triazin-4(3H)-yl]-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-07-8 4-[2-(4-chlorophenyl)-6-cyano-3,5-dioxo-2,5-dihydro-1,2,4-triazin-4(3H)-yl]-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 748148-57-4 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3-phenylacrylamide 
• 1627962-86-0 2-cyano-3-(4-methoxyphenyl)-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acrylamide 
• 1627962-87-1 3-(4-chlorophenyl)-2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acrylamide 
• 1627962-90-6 4‐(6‐amino‐4‐(4‐chlorophenyl)‐3,5‐dicyano‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide 

Relevant articles and documents

Computational studies and sever apoptotic bioactivity of new heterocyclic cyanoacrylamide based p-fluorophenyl and p-phenolic compounds against liver carcinoma (Hepg2)

An efficient route for the preparation of new heterocyclic cyanoacrylamides based p-fluorophenyl and p-phenolic compounds was depicted. All structures were confirmed based on the different spectral tools and elemental analyses. MTT assay for the novel syn

Synthesis and antimicrobial evaluation of some isoxazole based heterocycles

The versatile hitherto unreported 2-cyano-N-(4-{[(5-methylisoxazol- 3-yl)amino]sulfonyl}phenyl)acetamide (3) was utilized for the synthesis of a variety of heterocycles incorporating sulfamoyl moiety. The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with pentane-2,4-dione, arylidenes malononitrile, or terephthalaldehyde and malononitrile upon heating under reflux in the presence of a catalyst. Condensation of the cyanoacetamide 3 with salicylaldehyde furnished the corresponding chromene derivatives. Coupling of 3 with arene diazonium chlorides gave the hydrazone derivatives 13a-c, which upon treatment with hydrazine hydrate and ethyl chloroformate furnished the corresponding pyrazole and triazine derivatives, respectively. Reaction of 3 with carbon disulfide and 1,2-dibromoethane, 1,3-dibromopropane or dimethyl sulfate afforded 2-cyano-2-(1,3-dithiolan-2-ylidene)-N-(4-{[(5-methylisoxazol-3- yl)amino]sulfonyl}phenyl)acetamide (18), 2-cyano-2-(1,3-dithian-2-ylidene)-N- 4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide (19), and 2-cyano- N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio) acrylamide (20). The newly synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities, and showed promising results.