90484-53-0

Basic information

• Product Name: Methyl 3-broMo-4-forMylbenzoate
• Synonyms: Methyl 3-broMo-4-forMylbenzoate;3-Bromo-4-formyl-benzoic acid methyl ester
• CAS NO: 90484-53-0
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.05408
• Mol File: 90484-53-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 76.8-77.6℃
• Boiling Point: 326.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.566±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Methyl 3-broMo-4-forMylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-broMo-4-forMylbenzoate(90484-53-0)
• EPA Substance Registry System: Methyl 3-broMo-4-forMylbenzoate(90484-53-0)

Safety Data

• Hazardous Substances Data: 90484-53-0(Hazardous Substances Data)

Usage

General Description

Methyl 3-bromo-4-formylbenzoate is a chemical compound with the molecular formula C9H7BrO3. It is a member of the benzoate esters and is commonly used in organic synthesis and pharmaceutical research. Methyl 3-bromo-4-formylbenzoate is a white to light-yellow crystalline powder with a melting point of 124-126°C. Methyl 3-bromo-4-formylbenzoate is utilized as a key intermediate in the preparation of various pharmaceuticals and agrochemicals. It is also used as a building block for the synthesis of complex organic molecules and is known for its versatility in organic chemistry reactions. Additionally, it has applications in the production of fragrances and flavors due to its unique chemical structure.

Upstream product

• 1571-08-0 methyl 4-formylbenzoate 
• 78946-25-5 3-bromo-4-(bromomethyl)benzoic acid methyl ester 
• 42872-74-2 3-bromo-4-methyl-benzonitrile 
• 89892-39-7 3-bromo-4-(bromomethyl)benzonitrile 
• 1001200-40-3 methyl 3-bromo-4-(dibromomethyl)benzoate 
• 186581-53-3 diazomethane 
• 91760-66-6 3-bromo-4-formyl-benzoic acid 
• 90004-92-5 3-Brom-terephthalaldehydamid 
• 89891-69-0 3-bromo-4-formyl benzonitrile 

Downstream Products

• 1109244-73-6 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester 
• 1129606-97-8 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester 
• 813425-28-4 methyl 3-methyl-2-oxo-1,2-dihydroquinoline-7-carboxylate 
• 171239-90-0 methyl (E)-3-bromo-4-(4-(methoxycarbonyl)styryl)benzoate 
• 1610417-01-0 methyl 3-bromo-4-vinylbenzoate 

Relevant articles and documents

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INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE

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Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma

Melanin pigment represents an attractive target to address specific treatment to melanoma cells, such as cytotoxic radionuclides. However, less than half of the patients have pigmented metastases. Hence, specific marker is required to stratify this patient population before proceeding with melanin-targeted radionuclide therapy. In such a context, we developed fluorinated analogues of a previously studied melanin-targeting ligand, N-(2-diethylaminoethyl)-6-iodoquinoxaline-2-carboxamide (ICF01012). These latter can be labeled either with 18F or 131I/125I for positron emission tomography imaging (melanin-positive patient selection) and targeted radionuclide therapy purposes. Here we describe the syntheses, radiosyntheses and preclinical evaluations on melanoma-bearing mice model of several iodo- and fluoro(hetero)aromatic derivatives of the ICF01012 scaffold. After preliminary planar gamma scintigraphic and positron emission tomography imaging evaluations, [125I]- and [18F]-N-[2-(diethylamino)ethyl]-4-fluoro-3-iodobenzamides ([125I]4, [18F]4) were found to be chemically and biologically stable with quite similar tumor uptakes at 1 h p.i. (9.7 ± 2.6% ID/g and 6.8 ± 1.9% ID/g, respectively).