905281-14-3

Basic information

• Product Name: methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(5S)-2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl]-3-fluorophenyl}propanoate
• Synonyms: methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(5S)-2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl]-3-fluorophenyl}propanoate
• CAS NO: 905281-14-3
• Molecular Weight: 486.562
• Mol File: 905281-14-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(5S)-2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl]-3-fluorophenyl}propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(5S)-2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl]-3-fluorophenyl}propanoate(905281-14-3)
• EPA Substance Registry System: methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(5S)-2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl]-3-fluorophenyl}propanoate(905281-14-3)

Safety Data

• Hazardous Substances Data: 905281-14-3(Hazardous Substances Data)

Upstream product

• 850321-77-6 2-tert-butyl-5-[4-(dibromomethyl)-2-fluorophenyl]isothiazolidin-3-one 1,1-dioxide 
• 850321-78-7 4-(2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-fluorobenzaldehyde 
• 850321-76-5 2-tert-butyl-5-(2-fluoro-4-methylphenyl)isothiazolidin-3-one 1,1-dioxide 
• 850321-75-4 2-tert-butyl-5-(2-fluoro-4-methylphenyl)isothiazol-3(2H)-one 1,1-dioxide 
• 170981-26-7 2-fluoro-4-methylphenylboronic acid 
• 850314-47-5 2-tert-butyl-5-chloro-1,1-dioxo-1,2-dihydro-1λ⁶-isothiazol-3-one 
• 850321-79-8 methyl (2Z)-2-[(tert-butoxycarbonyl)amino]-3-[4-(2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-fluorophenyl]acrylate 

Downstream Products

• 905281-16-5 tert-butyl (1S)-1-(1H-benzimidazol-2-yl)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]-3-fluorophenyl}ethylcarbamate 

Relevant articles and documents

Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic

Potent nonpeptidic benzimidazole sulfonamide inhibitors of protein tyrosine phosphatase 1B (PTP1B) were derived from the optimization of a tripeptide containing the novel (S)-isothiazolidinone ((S)-IZD) phosphotyrosine (pTyr) mimetic. An X-ray cocrystal s