912-60-7

Basic information

• Product Name: NOSCAPINE HYDROCHLORIDE
• Synonyms: NOSCAPINE HYDROCHLORIDE;NARCOTINE HYDROCHLORIDE;(3S)-6,7-DIMETHOXY-3-[(5R)-5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL]-1(3H)-ISOBENZOFURANONE HYDROCHLORIDE;,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-;1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1;1-alpha-narcotinehydrochloride;capvalhydrochloride;coscopinhydrochloride
• CAS NO: 912-60-7
• Molecular Formula: C₂₂H₂₄NO₇*Cl
• Molecular Weight: 449.88
• EINECS: 213-014-9
• Product Categories: Inhibitors
• Mol File: 912-60-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 221-223 °C(lit.)
• Boiling Point: 565.3°Cat760mmHg
• Flash Point: 295.7°C
• Appearance: /
• Density: 1.332g/cm³
• Vapor Pressure: 8.42E-13mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
• Merck: 13,6752
• CAS DataBase Reference: NOSCAPINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NOSCAPINE HYDROCHLORIDE(912-60-7)
• EPA Substance Registry System: NOSCAPINE HYDROCHLORIDE(912-60-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 36
• RIDADR: 1544
• WGK Germany: 3
• RTECS: NP7225000
• F: 10
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 912-60-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 912-60-7 differently. You can refer to the following data:
1. topical fluoroquinolone antibiotic for acne
2. Anti-Tussive
3. Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.

Biological Activity

Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.

InChI:InChI=1/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/p+1/t17-,18+/m1/s1

Downstream Products

• 4593-97-9 N-Nor-1-methylcorypalline 
• 569-31-3 meconin 
• 550-10-7 hydrocotarnine 
• 19641-12-4 6-methoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-ol 
• 946068-67-3 (S)-6,7-dimethoxy-3-((R)-4-methoxy-9-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one