913631-66-0

Basic information

• Product Name: tert-butyl (1S,2R)-2-hydroxycyclopentylcarbaMate
• Synonyms: tert-butyl (1S,2R)-2-hydroxycyclopentylcarbaMate;(1R,2S)-cis-N-Boc-2-aminocyclopentanol;(1R,2S)-N-tert-Butoxycarbonyl-2-aminocyclopentanol;2-Methyl-2-propanyl [(1S,2R)-2-hydroxycyclopentyl]carbamate
• CAS NO: 913631-66-0
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.26276
• Mol File: 913631-66-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (1S,2R)-2-hydroxycyclopentylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (1S,2R)-2-hydroxycyclopentylcarbaMate(913631-66-0)
• EPA Substance Registry System: tert-butyl (1S,2R)-2-hydroxycyclopentylcarbaMate(913631-66-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 913631-66-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl (1S,2R)-2-hydroxycyclopentylcarbaMate is a chemical compound with the molecular formula C11H21NO3. It is an ester derivative of tert-butyl carbamate and has a cyclopentylcarbaMate moiety with a hydroxy group attached to the second carbon atom. tert-butyl (1S,2R)-2-hydroxycyclopentylcarbaMate is a chiral molecule, with a stereocenter at the first carbon atom and the second carbon atom. It is commonly used as a reagent in organic synthesis and pharmaceutical research. The tert-butyl group provides steric hindrance and stability to the molecule, making it a useful building block in the preparation of various biologically active compounds.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 225791-13-9 (1S,2R)-2-aminocyclopentanol hydrochloride salt 
• 415693-17-3 (1R,2S)-2-(p-dimethylaminobenzoyl)aminocyclopentanol 
• 930-45-0 (+/-)-cis-2-aminocyclopentanol 
• 260065-85-8 (1R,2S)-cis-2-aminocyclopentanol 

Relevant articles and documents

PIPERIDINE COMPOUNDS AS MENIN INHIBITORS

The present disclosure provides compounds represented by Formula (la): and the pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R2, R3, L, M and G are as defined as set forth in the specification. The present disclosure also provides compounds of Formula la for use to treat a condition or disorder responsive to menin inhibition such as cancer.

SMALL MOLECULE MENIN INHIBITORS

The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1b, R1c, E, G, and Q are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat cancer or any other disease, condition, or disorder that is responsive to inhibition of menin.

PIPERIDINES AS COVALENT MENIN INHIBITORS

The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, R1a, R1b, R1c, R1d, R2, R3, R8a, R8b, R10, X, Z2, m, and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer.