930-45-0

Basic information

• Product Name: Cyclopentanol,2-amino-,(1S,2S)-(9CI)
• Synonyms: Cyclopentanol,2-amino-,(1S,2S)-(9CI);(1S,2S)-2-aMinoclopentanol;(1S,2S)-2-aminoCyclopentanol
• CAS NO: 930-45-0
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Product Categories: VARIOUSAMINE
• Mol File: 930-45-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 78.5 °C
• Boiling Point: 179.4±33.0 °C(Predicted)
• Appearance: /
• Density: 1.084±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.93±0.40(Predicted)
• CAS DataBase Reference: Cyclopentanol,2-amino-,(1S,2S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanol,2-amino-,(1S,2S)-(9CI)(930-45-0)
• EPA Substance Registry System: Cyclopentanol,2-amino-,(1S,2S)-(9CI)(930-45-0)

Safety Data

• Hazardous Substances Data: 930-45-0(Hazardous Substances Data)

Usage

General Description

Cyclopentanol, 2-amino, (1S,2S)-(9CI), also known as (1S,2S)-2-Aminocyclopentanol, is a chemical compound with the molecular formula C5H11NO. It is a chiral compound, meaning it has a non-superimposable mirror image. Cyclopentanol,2-amino-,(1S,2S)-(9CI) is a bicyclic alcohol with an amino group attached to one of the carbon atoms in the cyclopentane ring. It has potential applications in pharmaceuticals, as a chiral building block for the synthesis of various pharmaceutical compounds. Cyclopentanol,2-amino-,(1S,2S)-(9CI) may also have applications in organic synthesis and chemical research as a reagent or intermediate. However, further research is needed to understand its full range of potential uses and properties.

Upstream product

• 198422-71-8 benzyl (1S,2S)-trans-N-(2-hydroxycyclopentyl)carbamate 
• 672310-36-0 (R,R)-2-N-benzyloxycarbonylaminocyclopentanol 
• 110716-79-5 (1R,2R)-trans-2-azidocyclopentanol 
• 33092-86-3 trans-2-aminocyclopentanol 
• 142-29-0 cyclopentene 
• 77644-10-1 (±)-trans-2-phthalimidocyclopentanol 
• 1360145-97-6 (1R,2R)-(-)-2-phthalimidocyclopentan-1-ol 
• 285-67-6 Cyclopentene oxide 
• 260065-68-7 (1R,2R)-trans-2-azidocyclopentyl acetate 
• 1360145-98-7 (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclopentane 
• 181657-56-7 (1S,2S)-2-(benzyloxy)cyclopentanamine 
• 68327-00-4 (+/-)-trans-2-(N-Benzylamino)cyclopentanol 
• 1033605-25-2 (1S,2S)-trans-2-(N-benzyl)amino-1-cyclopentanol 
• 125356-51-6 (1S,2S)-trans-2-azidocyclopentanol 

Downstream Products

• 33092-87-4 N-(2-hydroxycyclopentyl)benzamide 
• 145106-43-0 (1S,2S)-trans-2-(tert-butoxycarbonylamino)cyclopentanol 
• 816464-55-8 3-[(2,4-difluorophenyl)amino]-N-[(1R,2R)-2-hydroxycyclopentyl]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide 
• 1236422-83-5 trans-N-(2-hydroxy)cyclopropylphthalimide 
• 137328-52-0 (S,S)-N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamide 
• 1572511-94-4 C₁₉H₂₁FN₂O₄S 
• 415693-17-3 (1R,2S)-2-(p-dimethylaminobenzoyl)aminocyclopentanol 
• 145106-46-3 (S)-N-tert-butoxycarbonyl-2-aminocyclopentanone 
• 260065-85-8 (1R,2S)-cis-2-aminocyclopentanol 
• 913631-66-0 tert-butyl N-[(1S,2R)-2-hydroxycyclopentyl]carbamate 
• 454170-16-2 (1R,2R)-trans-2-(tertbutoxycarbonylamino)cyclopentanol 
• 5057-98-7 cis-1,2-cyclopentanediol 
• 120-92-3 cyclopentanone 

Relevant articles and documents

Enantioselective Cascade Biocatalysis for Deracemization of Racemic β-Amino Alcohols to Enantiopure (S)-β-Amino Alcohols by Employing Cyclohexylamine Oxidase and ω-Transaminase

Optically active β-amino alcohols are very useful chiral intermediates frequently used in the preparation of pharmaceutically active substances. Here, a novel cyclohexylamine oxidase (ArCHAO) was identified from the genome sequence of Arthrobacter sp. TYUT010-15 with the R-stereoselective deamination activity of β-amino alcohol. ArCHAO was cloned and successfully expressed in E. coli BL21, purified and characterized. Substrate-specific analysis revealed that ArCHAO has high activity (4.15 to 6.34 U mg?1 protein) and excellent enantioselectivity toward the tested β-amino alcohols. By using purified ArCHAO, a wide range of racemic β-amino alcohols were resolved, (S)-β-amino alcohols were obtained in >99 % ee. Deracemization of racemic β-amino alcohols was conducted by ArCHAO-catalyzed enantioselective deamination and transaminase-catalyzed enantioselective amination to afford (S)-β-amino alcohols in excellent conversion (78–94 %) and enantiomeric excess (>99 %). Preparative-scale deracemization was carried out with 50 mM (6.859 g L?1) racemic 2-amino-2-phenylethanol, (S)-2-amino-2-phenylethanol was obtained in 75 % isolated yield and >99 % ee.

Cyclic trans-β-amino alcohols: Preparation and enzymatic kinetic resolution

Enantioenriched cyclic β-amino alcohols, trans-2-aminocyclohexanols (ee, >99%), trans-2-aminocyclopentanols (ee, >99%), trans-1-amino-2- indanols (ee, >99%) and trans-2-amino-1-indanols (ee, ～98%) were prepared in high yields via an Arthrobacter sp. Lipase/PLAP catalyzed kinetic resolution of racemic phthalimido acetates. The addition of toluene as a co-solvent dramatically improved the hydrolysis and enantioselectivity, whereas for indanols, substrate immobilization on Celite improved the efficacy of the kinetic resolution.

cis-Cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization.

DNA/RNA hybridization studies of PNA-T oligomers with cis-(1S,2R/1R,2S)-cyclopentyl units in the backbone show stereochemistry dependent binding with RNA/DNA discrimination.