91374-22-0

Basic information

• Product Name: 2-Methyl-3-nitro-N,N-dipropylphenylacetamide
• Synonyms: 2-METHYL-3-NITRO-N,N-DIPROPYLBENZENEACETAMIDE;2-Methyl-3-nitro-N,N-dipropylphenylacetamide;(2-METHYL-3-NITROPHENYL) N,N-DIPROPYLACETAMIDE;BENZENEACETAMIDE, 2-METHYL-3-NITRO- N,N-DIPROPYL-;N,N,-Dipropyl-2-Methyl-3-Nitro- phenyl Acetamide;2-Methy1-3-nitro-N,N-dipropylphenylacetaMide;2-Methyl-3-nitro-N,N;2-(3-Nitrophenyl)-N,N-dipropylpropanaMide
• CAS NO: 91374-22-0
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.35
• Product Categories: Pharmaceutical material and intermeidates;Medicine intermediate;Benzene derivates
• Mol File: 91374-22-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 49-50 °C
• Boiling Point: 429.6 °C at 760 mmHg
• Flash Point: 213.6 °C
• Appearance: /
• Density: 1.096 g/cm³
• Vapor Pressure: 1.39E-07mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: 2-8°C
• PKA: -0.67±0.70(Predicted)
• CAS DataBase Reference: 2-Methyl-3-nitro-N,N-dipropylphenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-nitro-N,N-dipropylphenylacetamide(91374-22-0)
• EPA Substance Registry System: 2-Methyl-3-nitro-N,N-dipropylphenylacetamide(91374-22-0)

Safety Data

• Hazardous Substances Data: 91374-22-0(Hazardous Substances Data)

Usage

General Description

2-Methyl-3-nitro-N,N-dipropylphenylacetamide is a chemical compound that belongs to the category of acetamides. It is a yellowish crystalline solid with a molecular formula C15H23N3O3. 2-Methyl-3-nitro-N,N-dipropylphenylacetamide is a nitrophenylacetamide derivative, and its structure includes a nitro group, a methyl group, and two propyl groups attached to a phenyl ring. 2-Methyl-3-nitro-N,N-dipropylphenylacetamide may have potential applications in various fields such as pharmaceuticals, agrochemicals, and research due to its unique chemical properties. However, further studies are needed to fully investigate its potential uses and properties.

InChI:InChI=1/C15H22N2O3/c1-4-9-16(10-5-2)15(18)11-13-7-6-8-14(12(13)3)17(19)20/h6-8H,4-5,9-11H2,1-3H3

Upstream product

• 142-84-7 di-n-propylamine 
• 101566-00-1 2-methyl-3-nitrophenylethanoyl chloride 
• 23876-15-5 2-(3-nitro-2-methylphenyl)acetic acid 
• 60468-54-4 1-chloromethyl-2-methyl-3-nitro-benzene 
• 23876-14-4 3-nitro-2-methylphenylacetonitrile 
• 23876-13-3 (2-methyl-3-nitrophenyl)methanol 
• 1975-50-4 2-methyl-3-nitrobenzic acid 

Downstream Products

• 91374-23-1 1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene 
• 91374-25-3 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride 
• 97351-95-6 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>pyruvic acid 
• 720656-64-4 2-nitro-6-<2-(di-n-propylamino)ethyl>phenylacetic acid 
• 91374-21-9 Ropinirole 

Relevant articles and documents

Comprehensive Study of the Organic-Solvent-Free CDI-Mediated Acylation of Various Nucleophiles by Mechanochemistry

Acylation reactions are ubiquitous in the synthesis of natural products and biologically active compounds. Unfortunately, these reactions often require the use of large quantities of volatile and/or toxic solvents, either for the reaction, purification or isolation of the products. Herein we describe and discuss the possibility of completely eliminating the use of organic solvents for the synthesis, purification and isolation of products resulting from the acylation of amines and other nucleophiles. Thus, utilisation of N,N′-carbonyldiimidazole (CDI) allows efficient coupling between carboxylic acids and various nucleophiles under solvent-free mechanical agitation, and water-assisted grinding enables both the purification and isolation of pure products. Critical parameters such as the physical state and water solubility of the products, milling material, type of agitation (vibratory or planetary) as well as contamination from wear are analysed and discussed. In addition, original organic-solvent-free conditions are proposed to overcome the limitations of this approach. The calculations of various green metrics are included, highlighting the particularly low environmental impact of this strategy.

Syntheses and in Vitro Evaluation of 4-(2-Aminoethyl)-2(3H)-indolones and Related Compounds as Peripheral Prejunctional Dopamine Receptor Agonists

A series of (β-aminoethyl)indolones and related compounds was synthesized and evaluated in vitro as peripheral prejunctional dopaminergic agonists in the field-stimulated isolated perfused rabbit ear artery. 4--7-hydroxy-2(3H)-indolone (26) was the most potent compound (ED50 = 2 +/- 0.3 nM) tested, while the related secondary amine 24 and the des-OH derivatives 28 and 34 were only slightly less potent. 4-Methoxy-benzeneethanamine and 2-methyl-3-nitrophenylacetic acid were employed as starting materials for the synthesis of the 4-(β-aminoethyl)indolones.The ring-opened 3-acylamino analogues 46 and 47 were prepared via nitration of the phenethylamine 43 derived from 4-methoxyphenylacetic acid.The inactive isomeric indolones 38, 39, and 41 were derived from 4-nitrobenzeneethanamine and from indolone-6-acetic acid (13).

4--2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist

4--2(3H)-indolone (1c) (SK and F 101468) is a potent and selective prejunctional dopamine receptor agonist.It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (EC50 = 100 nM), and this response was antagonized by (S)-sulpiride (KB = 7 nM).Compound 1c did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce stimulation of the central nervous system in rats.It was prepared from (2-methyl-3-nitrophenyl)acetic acid in a multistep sequence based on the Reissert indole synthesis.