91374-25-3

Basic information

• Product Name: 2-[2-(Dipropylamino)ethyl]-6-nitrophenylacetic acid hydrochloride
• Synonyms: 2-[2-(DIPROPYLAMINO)ETHYL]-6-NITRO-PHENYL ACETIC ACID HCL;2-[2-(Dipropylamino)ethyl]-6-Nitro-Phenyl Acetic Acid Hydrochloride;2-nitro-6-[2-(n,n-di-n-propylamino)ethyl]phenyl]acetic acid hcl;[2-Nitro-6-(2-dipropylaminoethyl)phenyl]acetic acid hydrochloride;2-[2-(Dipropylamino)ethyl]-6-nitro-benzeneacetic acid, hydrochloride(1:1);2-[2-(DipropylaMino)ethyl]-6-nitrobenzeneacetic Acid Hydrochloride;Nitro Ropinirole(USP Open Ring NitroDerivative);2-(2-(2-(Dipropylamino)ethyl)-6-nitrophenyl)-acetic acid hydrochloride
• CAS NO: 91374-25-3
• Molecular Formula: C₁₆H₂₄N₂O₄*ClH
• Molecular Weight: 344.83
• Product Categories: Pharmaceutical material and intermeidates;Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 91374-25-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 188-192 °C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-[2-(Dipropylamino)ethyl]-6-nitrophenylacetic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(Dipropylamino)ethyl]-6-nitrophenylacetic acid hydrochloride(91374-25-3)
• EPA Substance Registry System: 2-[2-(Dipropylamino)ethyl]-6-nitrophenylacetic acid hydrochloride(91374-25-3)

Safety Data

• Hazardous Substances Data: 91374-25-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale YellowSolid

Uses

A metabolite of Ropinirole (R641000).

InChI:InChI=1/C16H24N2O4.ClH/c1-3-9-17(10-4-2)11-8-13-6-5-7-15(18(21)22)14(13)12-16(19)20;/h5-7H,3-4,8-12H2,1-2H3,(H,19,20);1H

Upstream product

• 97351-95-6 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>pyruvic acid 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 23876-13-3 (2-methyl-3-nitrophenyl)methanol 
• 23876-15-5 2-(3-nitro-2-methylphenyl)acetic acid 
• 23876-14-4 3-nitro-2-methylphenylacetonitrile 
• 920986-68-1 N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride 
• 91374-24-2 ethyl 6-[2-(di-n-propylamino)ethyl]-2-nitrophenyl pyruvate 
• 91374-22-0 2-(2-methyl-3-nitro-phenyl)-N,N-di-n-propylacetamide 
• 91374-23-1 1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene 
• 101566-00-1 2-methyl-3-nitrophenylethanoyl chloride 
• 60468-54-4 1-chloromethyl-2-methyl-3-nitro-benzene 

Downstream Products

• 91374-20-8 ropinirole hydrochloride 
• 91374-21-9 Ropinirole 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF

The present invention relates to an improved process for the preparation of Ropinirole and pharmaceutical acceptable salts or derivatives thereof, in particular to a process for large scale production of Ropinirole and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds.

PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE

A process for the preparation of 4-[2-(Di-n-propylamino) ethyl]-2,3-dihydro-1 H-indol-2-one of formula (I) and its pharmaceutically acceptable salts, solvates Formaula I involving new intermediates of compound of formula (A) and (B) wherein R represents (i) a halogen atom selected from fluorine, chlorine atom, bromine atom and iodine atom; (ii) lower alkanesulfonyloxy group selected from methanesulfonyloxy, ethanesulfonyloxy, isopropanesulfonyloxy, propanesulfonyloxy, butanesulfonyloxy, tert-butanesulfonyloxy, pentanesulfonyloxy, hexanesulfonyloxy; (iii) substituted or unsubstantiated arylsulfonyloxy group selected from phenylsulfonyloxy, 4-methylphenylsulfonyloxy, 2-methylphenylsulfonyloxy, 4- nitrophenylsulfonyloxy, 4- methoxyphenylsulfonyloxy, 3-chlorophenylsulfonyloxy; (iv) arylalkylsulfonyloxy group selected from benzylsulfonyloxy, 2- phenylethylsulfonyloxy, 4-phenylbutylsulfonyloxy, 4- methylbenzylsulfonyloxy, 2- methylbenzylsulfonyloxy, 4- nitrobenzylsulfonyloxy, 4-methoxybenzylsulfonyloxy, 3- chlorobenzylsulfonyloxy.