916664-23-8

Basic information

• Product Name: 2-azido 5-chlorobenzaldehyde
• Synonyms: 2-azido 5-chlorobenzaldehyde
• CAS NO: 916664-23-8
• Molecular Weight: 181.581
• Mol File: 916664-23-8.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-azido 5-chlorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-azido 5-chlorobenzaldehyde(916664-23-8)
• EPA Substance Registry System: 2-azido 5-chlorobenzaldehyde(916664-23-8)

Safety Data

• Hazardous Substances Data: 916664-23-8(Hazardous Substances Data)

Upstream product

• 220630-32-0 (2-azido-5-chlorophenyl)methanol 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 587-04-2 m-Chlorobenzaldehyde 
• 96515-79-6 5-chloro-2-fluorobenzaldehyde 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 

Downstream Products

• 1279718-30-7 C₈H₇ClN₄O₃ 
• 213542-01-9 5-chloro-3-nitro-1H-indole 
• 1334951-08-4 5-chloro-2-(4-methoxyphenyl)-2H-indazole 

Relevant articles and documents

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Factor XIa (FXIa) is an enzyme in the coagulation cascade thought to amplify thrombin generation but has a limited role in hemostasis. From preclinical models and human genetics, an inhibitor of FXIa has the potential to be an antithrombotic agent with superior efficacy and safety. Reversible and irreversible inhibitors of FXIa have demonstrated excellent antithrombotic efficacy without increased bleeding time in animal models (Weitz, J. I., Chan, N. C. Arterioscler. Thromb. Vasc. Biol. 2019, 39 (1), 7-12). Herein, we report the discovery of a novel series of macrocyclic FXIa inhibitors containing a pyrazole P2′ moiety. Optimization of the series for (pharmacokinetic) PK properties, free fraction, and solubility resulted in the identification of milvexian (BMS-986177/JNJ-70033093, 17, FXIa Ki = 0.11 nM) as a clinical candidate for the prevention and treatment of thromboembolic disorders, suitable for oral administration.

2-[3-(ALKYLSULFONYL)-2H-INDAZOL-2-YL]-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PESTICIDES

The invention relates to compounds of the formula (Ia) or (Ib), in which Aa, Ab, Ac, Ad, R1, R10 R11, R12, R13, R14, R15, R16, R17, Q, R4, R5, R

Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones

A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI-catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of fused-tetrahydrobenzodiazepin-3-ones.