91892-39-6Relevant articles and documents
Triazines and Related Products. Part 26. Synthesis and Chemistry of Bicyclic Analogues of the Antitumour Drug 2,4,6-Tris(dimethylamino)-1,3,5-triazine (Hexamethylmelamine)
Langdon, Simon P.,Simmonds, Richard J.,Stevens, Malcolm F. G.
, p. 993 - 998 (2007/10/02)
Interaction of 2,4-bis(dimethylamino)-6-hydrazino-1,3,5-triazine (1c) with aryl aldehydes yields a series of aryl hydrazones (4) which cyclise to 3-aryl-5,7-bis(dimethylamino)-1,2,4-triazolotriazines (6) with lead(VI) acetate in dichloromethane.Rearrangement of these bicycles in methanolic sodium hydroxide affords stable isomeric 2-aryl-5,7-bis(dimethylamino)triazolotriazines (7).Selected examples from both series of triazolotriazines were screened against the mouse M5076 reticulum cell sarcoma and P388 leukaemia in vivo but proved to have no antitumour activity.