923-61-5 Usage
Description
1,2-Dipalmitoyl-sn-glycero-3-PE (1,2-DPPE) is a naturally occurring PE containing C16:0 fatty acids at the sn-1 and sn-2 positions. It belongs to a class of phospholipids that are the most abundant lipids in the inner leaflet of the plasma membrane. 1,2-DPPE interacts with cholesterol to form a condensed lipid monolayer with tight hydrogen bonding of the 1,2-DPPE interheadgroups, resulting in a more fluid membrane that may aid in transport and signaling across the bilayer. 1,2-Dipalmitoyl-sn-glycero-3-PE MaxSpec? standard is a quantitative grade standard of 1,2-dipalmitoyl-sn-glycero-3-PE that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 1,2-dipalmitoyl-sn-glycero-3-PE MaxSpec? standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Uses
Different sources of media describe the Uses of 923-61-5 differently. You can refer to the following data:
1. 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is used in model membrane .
2. 16:0 PE has been used:for the preparation of perfluorocarbon (PFC) nanoparticlesfor lipid binding by liposome flotation assaysto characterize the metabolic fate of synaptamide in a dopaminergic cell line
Definition
ChEBI: A 1,2-diacyl-sn-glycero-3-phosphoethanolamine in which the 1- and 2-acyl groups are both specified as hexadecanoyl (palmitoyl).
General Description
Phosphatidylethanolamine is an aminophospholipid. It is present in eukaryotic and prokaryotic cells. Phosphatidylethanolamine is one of the most abundant glycerophospholipids in biological membranes. It is found in nervous tissue.
Biochem/physiol Actions
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phospholipid, a lipid component in cell membrane .
Check Digit Verification of cas no
The CAS Registry Mumber 923-61-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,2 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 923-61:
(5*9)+(4*2)+(3*3)+(2*6)+(1*1)=75
75 % 10 = 5
So 923-61-5 is a valid CAS Registry Number.
923-61-5Relevant articles and documents
1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine and preparation method thereof
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Paragraph 0048; 0073-0085, (2019/10/23)
The invention provides 1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine and a preparation method thereof. The preparation method comprises the following steps: S1, performing a nucleophilic substitution reaction on glyceryldipalmitate and POCl3 under the action of tetrahydrofuran and alkali, and purifying a reaction product after completion of the reaction to obtain an intermediate 1, wherein theintermediate 1 is (R)-3-((dichlorophosphoryl)oxy)propane-1,2-dipalmitic acid; S2, performing a nucleophilic substitution reaction on the intermediate 1 and N-Fmoc-ethanolamine under the action of tetrahydrofuran and alkali, and purifying a reaction product after completion of the reaction to obtain an intermediate 2, wherein the intermediate 2 is (R)-3-(((2-( fluorenylmethoxy carbonylamino)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-dipalmitate; and S3, performing a nucleophilic substitution reaction on the intermediate 2 under the action of a solvent and alkali to obtain the 1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine. According to the preparation method provided by the embodiment of the invention, a final product is relatively high in purity, and byproducts are few.
Chelating agents with lipophilic carriers
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, (2008/06/13)
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.
Method of lowering the viscosity of mucus
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, (2008/06/13)
The use of phospholipids of the following formula to reduce the viscosity of mucus in a patient is described: STR1 wherein one of X, Y, or Z represent: STR2 in which each R represents hydrogen or methyl, and each of the other two of X, Y, or Z represents --CO--R1 in which R1 represents linear or branched C11-21 alkyl or C11-21 alkenyl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C1-6 linear or branched alkoxy or cyano.
