923289-30-9

Basic information

• Product Name: Ethanone,1-(2-amino-3-bromo-4-methoxyphenyl)-
• Synonyms: Ethanone,1-(2-amino-3-bromo-4-methoxyphenyl)-;1-(2-Amino-3-bromo-4-methoxyphenyl)ethanone;thanone,1-(2-aMino-3-broMo-4-Methoxyphenyl)-;1-(2-amino-3-bromo-4-methoxyphenyl)ethan-1-one
• CAS NO: 923289-30-9
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• EINECS: 920-420-6
• Mol File: 923289-30-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 367.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.493±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.18±0.10(Predicted)
• CAS DataBase Reference: Ethanone,1-(2-amino-3-bromo-4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-(2-amino-3-bromo-4-methoxyphenyl)-(923289-30-9)
• EPA Substance Registry System: Ethanone,1-(2-amino-3-bromo-4-methoxyphenyl)-(923289-30-9)

Safety Data

• Hazardous Substances Data: 923289-30-9(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-amino-3-bromo-4-methoxyphenyl)-, also known as 2-Amino-3-bromo-4-methoxyacetophenone, is a chemical compound with the formula C10H10BrNO2. It is a brominated and methoxylated derivative of acetophenone, which is a common building block in organic synthesis. Ethanone,1-(2-amino-3-bromo-4-methoxyphenyl)- is used in the pharmaceutical and chemical industries as an intermediate for the synthesis of various organic compounds. It has also been studied for its potential biological activities, including its antibacterial and anticancer properties. Overall, ethanone, 1-(2-amino-3-bromo-4-methoxyphenyl)- is a versatile chemical with a range of potential applications in research and industry.

Upstream product

• 112970-44-2 2-bromo-3-methoxyaniline 
• 75-05-8 acetonitrile 
• 67853-38-7 2-bromo-3-methoxyphenylamine hydrochloride 

Downstream Products

• 1108658-98-5 N-(6-acetyl-2-bromo-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 
• 923289-31-0 C₁₃H₁₁BrN₂O₃S 
• 1219105-45-9 C₁₇H₁₈BrN₃O₄S 
• 1245553-60-9 N-(6-acetyl-2-bromo-3-methoxyphenyl)-2-(isopropylamino)-thiazole-4-carboxamide 

Relevant articles and documents

CRYSTALLINE FORMS OF A 2-THIAZOLYL- 4-QUINOLINYL-OXY DERIVATIVE, A POTENT HCV INHIBITOR

This invention relates to novel crystalline forms of the following Compound (1), and the sodium salt thereof, and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection.

Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors

Starting from the previously reported HCV NS3/4A protease inhibitor BILN 2061 (1), we have used a fast-follower approach to identify a novel series of HCV NS3/4A protease inhibitors in which (i) the P3 amino moiety and its capping group have been truncated, (ii) a sulfonamide is introduced in the P1 cyclopropyl amino acid, (iii) the position 8 of the quinoline is substituted with a methyl or halo group, and (iv) the ring size of the macrocycle has been reduced to 14 atoms. SAR analysis performed with a limited set of compounds led to the identification of N-{17-[8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-2,14-dioxo-3,15-diazatricyclo [13.3.0.0 [Bartenschlager, R.; Lohmann, V. J. Gen. Virol. 2000, 81, 1631; Vincent Soriano, Antonio Madejon, Eugenia Vispo, Pablo Labarga, Javier Garcia-Samaniego, Luz Martin-Carbonero, Julie Sheldon, Marcelle Bottecchia, Paula Tuma, Pablo Barreiro Expert Opin. Emerg. Drugs, 2008, 13, 1-19]]octadec-7-ene-4-carbonyl}(1-methylcyclopropyl)(1-methylcyclopropyl)sulfonamide 19l an extremely potent (Ki = 0.20 nM, EC50 = 3.7 nM), selective, and orally bioavailable dipeptide NS3/4A protease inhibitor, which has features attractive for further preclinical development.