92765-75-8

Basic information

• Product Name: 2-(1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE
• Synonyms: 2-(1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE;RARECHEM AL BP 0183;2-(1,3-Dioxolan-2-yl)-6-methylpyridine,95%;2-(1,3-Dioxolan-2-yl
• CAS NO: 92765-75-8
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.19
• Product Categories: Heterocyclic Compounds;C9 to C46;Heterocyclic Building Blocks;Pyridines
• Mol File: 92765-75-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 124-126 °C(lit.)
• Boiling Point: 218 °C(lit.)
• Flash Point: 218 °F
• Appearance: /
• Density: 1.132 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0139mmHg at 25°C
• Refractive Index: n20/D 1.5220(lit.)
• Storage Temp.: Refrigerator (+4°C)
• CAS DataBase Reference: 2-(1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE(92765-75-8)
• EPA Substance Registry System: 2-(1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE(92765-75-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 92765-75-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-7-3-2-4-8(10-7)9-11-5-6-12-9/h2-4,9H,5-6H2,1H3

Upstream product

• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 
• 107-21-1 ethylene glycol 
• 646-06-0 1,3-DIOXOLANE 
• 109-06-8 α-picoline 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 

Downstream Products

• 1187836-48-1 N-[(6-{[(cyclohexyloxy)imino]methyl}pyridin-2-yl)methoxy]-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 
• 1187835-33-1 N-{[6-(1,3-dioxolan-2-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 
• 1187836-49-2 {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}methanol 
• 1187835-51-3 N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 
• 1187835-48-8 6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridine-2-carbaldehyde 

Relevant articles and documents

A facile synthesis of an (E)-4-methyl-4-hexenoic acid substituted pyridine analogue of mycophenolic acid

An (E)-4-methyl-4-hexenoic acid substituted pyridine analogue, 2, of mycophenolic acid has been synthesized from 6-methyl-2-pyridine-carboxaldehyde in 6 steps via a Claisen rearrangement.

Transition-Metal-Free Regioselective Alkylation of Pyridine N-Oxides Using 1,1-Diborylalkanes as Alkylating Reagents

Reported herein is an unprecedented base-promoted deborylative alkylation of pyridine N-oxides using 1,1-diborylalkanes as alkyl sources. The reaction proceeds efficiently for a wide range of pyridine N-oxides and 1,1-diborylalkanes with excellent regioselectivity. The utility of the developed method is demonstrated by the sequential C?H arylation and methylation of pyridine N-oxides. The reaction also can be applied for the direct introduction of a methyl group to 9-O-methylquinine N-oxide, thus it can serve as a powerful method for late-stage functionalization.

Bis(oxazoline) lewis acid catalyzed aldol reactions of pyridine N-oxide aldehydes-synthesis of optically active 2-(1-hydroxyalkyl)pyridine derivatives: Development, scope, and total synthesis of an indolizine alkaloid

A new. short, and simplified procedure for the synthesis of optically active pyridine derivatives from prochiral pyridine-N-oxides is presented. The catalytic and asymmetric Mukaiyama aldol reaction between ketene silyl acetals and l-oxypyridine-2-carhaldehyde derivatives catalyzed by chiral copper(ii)-bis(oxazoline) complexes gave optically active 2-(hydroxyalkyl)-and 2-(anti-1.2-dihydroxyalkyl)pyridine derivatives in good yields and diastereoselectivities, and in excellent enantioselectivities - up to 99% enantiomeric excess. As a synthetic application of the developed method, a full account for the asymmetric total synthesis of a nonnatural indolizine alkaloid is provided.