928149-12-6

Basic information

• Product Name: (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate
• Synonyms: (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate;(1,1-Dioxidotetrahydrothiopyran-4-yl)methyl 4-Methylbenzenesulfonate;4-(Tosyloxylmethyl)tetrahydrothiopyran-1,1-dioxide
• CAS NO: 928149-12-6
• Molecular Formula: C₁₃H₁₈O₅S₂
• Molecular Weight: 318.40902
• Mol File: 928149-12-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 537.3±23.0 °C(Predicted)
• Appearance: /
• Density: 1.310±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate(928149-12-6)
• EPA Substance Registry System: (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate(928149-12-6)

Safety Data

• Hazardous Substances Data: 928149-12-6(Hazardous Substances Data)

Usage

General Description

The chemical compound "(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate" is a sulfonate derivative that consists of a 4-methylbenzenesulfonate group attached to a (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl group. It is commonly used as a reagent in organic synthesis, particularly in the preparation of sulfonate esters. Sulfonate esters are important intermediates in a wide range of chemical processes, including the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. The compound may also have other potential applications in various industries such as pharmaceuticals, agrochemicals, and material science. Its properties and potential uses make it a valuable and versatile chemical in organic chemistry.

Upstream product

• 64096-87-3 1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carboxylic acid 
• 195503-40-3 tetrahydro-2H-thiopyrane-4-carbonitrile 
• 89489-53-2 tetrahydro-2H-thiopyran-4-carboxylic acid 
• 1072-72-6 Tetrahydrothiopyran-4-one 
• 100277-27-8 (tetrahydro-2H-thiopyran-4-yl)methanol 
• 473254-28-3 (1,1-dioxo-hexahydro-1-thiopyran-4-yl)-methanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1453861-64-7 ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-39-6 ethyl 2-(3-(4-((4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 

Relevant articles and documents

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

SUBSTITUTED BENZOTHIOPHENYL DERIVATIVES AS GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) wherein R1, R2, R3, R5, R6, W, and A are defined herein.

PHENYL ALKANOIC ACID DERIVATIVES AS GPR AGONISTS

The present invention relates to phenyl alkanoic acid derivatives (the compounds of Formula (I)); and their isotopic forms, stereoisomeric and tautomeric forms and mixtures thereof in all ratios, or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, polymorphs, N-oxides, S-oxides or carboxylic acid isosteres thereof. The invention also relates to processes for the preparation of compounds of Formula (I) and pharmaceutical compositions comprising one or more of the compounds of Formula (I). The said compounds and the pharmaceutical composition function as GPR (G-protein coupled receptor) agonists, particularly as GPR40 agonists, and are useful in the treatment of diseases or conditions mediated by GPR40. The present invention further relates to a method of treatment of diseases or conditions mediated by GPR40comprising administering to a subject in need thereof a therapeutically effective amount of the compounds of Formula (I).