92950-40-8

Basic information

• Product Name: 2'-ACETYLTAXOL
• Synonyms: ACETYLTAXOL, 2'-;2'-ACETYLTAXOL
• CAS NO: 92950-40-8
• Molecular Formula: C₄₉H₅₃NO₁₅
• Molecular Weight: 895.94
• Mol File: 92950-40-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 956.3°Cat760mmHg
• Flash Point: 532.1°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 2'-ACETYLTAXOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-ACETYLTAXOL(92950-40-8)
• EPA Substance Registry System: 2'-ACETYLTAXOL(92950-40-8)

Safety Data

• Hazardous Substances Data: 92950-40-8(Hazardous Substances Data)

Usage

Uses

2''-Acetyltaxol is a microtubule polymerization-inactive taxol analog.

InChI:InChI=1/C49H53NO15/c1-26-33(63-45(58)39(62-28(3)52)37(30-17-11-8-12-18-30)50-43(56)31-19-13-9-14-20-31)24-49(59)42(64-44(57)32-21-15-10-16-22-32)40-47(7,34(54)23-35-48(40,25-60-35)65-29(4)53)41(55)38(61-27(2)51)36(26)46(49,5)6/h8-22,33-35,37-40,42,54,59H,23-25H2,1-7H3,(H,50,56)/t33-,34-,35+,37-,38+,39+,40-,42-,47+,48-,49+/m0/s1

Upstream product

• 108-05-4 vinyl acetate 
• 33069-62-4 taxol 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 90332-63-1 7-O-(β-xylosyl)-10-deacetyltaxol 
• 78432-77-6 10-deacetylpaclitaxel 

Downstream Products

• 171780-98-6 2'-O-acetyl-7-trifluoromethanesulfonyl-paclitaxel 
• 33069-62-4 taxol 
• 100431-63-8 2'-acetyl-7-oxo-5,O-secotaxol 
• 100431-60-5 2'-acetyl-7-oxo-5,6-dehydro-5,O-secotaxol 
• 171780-95-3 2'-O-acetyl-Δ^6,7-paclitaxel 
• 171780-96-4 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ^6,7-20-O-seco-paclitaxel 
• 158830-49-0 Δ^6,7-paclitaxel 
• 100431-54-7 2'-acetyl-7-oxotaxol 

Relevant articles and documents

Process of synthesizing paclitaxel from 10-deacetyltaxol

The invention relates to a process of synthesizing paclitaxel from 10-deacetyltaxol (10-DAT). The process includes: taking 10-DAT as the starting raw material, conducting acetic anhydride acetylation,and under an alkaline condition, hydrolyzing the 2'-acetyl with dimethylamine to obtain paclitaxel. The route has the characteristics of short steps, shortened production cycle, no need for side chain, and reduction of the raw material cost.

METHOD FOR THE PREPARATION OF SYNTHESIZED TAXANOIDS

The present invention relates to a process for the preparation of synthetic taxanes, which protects C(7)-OH with lanthanon compounds. Its advantages are simple process and firm & reliable binding. Moreover, no C(7)-acylated taxanes are produced in the subsequent steps, and hydrolysis of C(2')-ester groups in acylated products becomes readily controllable. In the process for the preparation of synthetic taxanes, tetrahydrofuran is used in the present invention as a medium for acylation, which not only achieves the same effects as pyridine, but also avoids odor, so as to solve the problem regarding the extremely high requirements for the place of production. The present invention can be used for the preparation of not only semi-synthetic taxane using natural taxanes as raw material, but also full-synthetic taxane.

Synthesis of water-soluble paclitaxel derivatives by enzymatic acylation [10]

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