171780-96-4

Basic information

• Product Name: 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ^6,7-20-O-seco-paclitaxel
• Synonyms: 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ^6,7-20-O-seco-paclitaxel
• CAS NO: 171780-96-4
• Molecular Weight: 853.92
• Mol File: 171780-96-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ^6,7-20-O-seco-paclitaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ^6,7-20-O-seco-paclitaxel(171780-96-4)
• EPA Substance Registry System: 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ^6,7-20-O-seco-paclitaxel(171780-96-4)

Safety Data

• Hazardous Substances Data: 171780-96-4(Hazardous Substances Data)

Upstream product

• 33069-62-4 taxol 
• 171780-98-6 2'-O-acetyl-7-trifluoromethanesulfonyl-paclitaxel 
• 171781-02-5 C₄₈H₅₀F₃NO₁₆S 
• 171869-48-0 2'-O-acetyl-7α-methanesulfonyl-paclitaxel 
• 171780-95-3 2'-O-acetyl-Δ^6,7-paclitaxel 
• 172586-62-8 2'-O-acetyl-7α-paclitaxel 
• 92950-40-8 2'-O-acetyl-paclitaxel 
• 148930-54-5 (2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate 
• 158830-49-0 Δ^6,7-paclitaxel 

Relevant articles and documents

Synthesis and Molecular Modeling of Taxanes Modified at Ring C

Some new paclitaxel analogs, modified at ring C, - namely the 7-α-mesylate, 7-deoxy-7-α-amino, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco and 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco derivatives - are presented. The biological activity of 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco, 7-deoxy-7-α-azido, 7-deoxy-7-α-amino and 6,7-epoxy derivatives heve been evaluated. A molecular modeling study on some paclitaxel derivatives has been done in an attempt to rationalize the difference in biological activity.