930113-25-0

Basic information

• Product Name: 3-(3-methylphenyl)-imidazo[1,2-a]pyridine
• Synonyms: 3-(3-methylphenyl)-imidazo[1,2-a]pyridine
• CAS NO: 930113-25-0
• Molecular Weight: 208.263
• Mol File: 930113-25-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-(3-methylphenyl)-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-methylphenyl)-imidazo[1,2-a]pyridine(930113-25-0)
• EPA Substance Registry System: 3-(3-methylphenyl)-imidazo[1,2-a]pyridine(930113-25-0)

Safety Data

• Hazardous Substances Data: 930113-25-0(Hazardous Substances Data)

Upstream product

• 274-76-0 imidazo[1,2-a]pyridine 
• 591-17-3 meta-bromotoluene 
• 504-29-0 2-aminopyridine 
• 97065-56-0 1-(2,2-dibromovinyl)-3-methylbenzene 
• 1077-02-7 3-methylphenyl methanesulfonate 
• 108-41-8 1-chloro-3-methylbenzene 
• 625-95-6 3-Iodotoluene 
• 6200-60-8 imidazo[1,2-a]pyridine-3-carboxylic acid 
• 108-88-3 toluene 

Relevant articles and documents

Regioselective direct c-3 arylation of imidazo[1,2- a ]pyridines with aryl tosylates and mesylates promoted by palladium-phosphine complexes

Direct C-3 arylation of imidazo[1,2-a]pyridines with aryl tosylates and mesylates has been accomplished by employing palladium(II) acetate associated with SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl) or L1 (2-(2-(diisopropylphosphino)phenyl)-1-methyl-1H-indole). This catalyst system can be applied to a wide range of aryl sulfonates and shows excellent C-3 regioselectivity of imidazo[1,2-a]pyridine. These results represent the first examples of using tosylate- and mesylate-functionalized arenes as the electrophile partners for this regioselective direct arylation.

N-Heterocyclic carbene-palladium(ii)-1-methylimidazole complex catalyzed direct C-H bond arylation of imidazo[1,2-a]pyridines with aryl chlorides

We herein reported the N-heterocyclic carbene-palladium(ii)-1-methylimidazole complex catalyzed direct C-H bond arylation of imidazo[1,2-a]pyridines with aryl chlorides. Under suitable conditions, all reactions between various imidazo[1,2-a]pyridines and

An unprecedented Pd-catalyzed decarboxylative coupling reaction of aromatic carboxylic acids in aqueous medium under air: Synthesis of 3-aryl-imidazo[1,2-a]pyridines from aryl chlorides

An efficient and practical protocol for palladium-catalyzed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with aryl chlorides has been developed. Note that the reaction could proceed smoothly without an additive in aqueous medium under an ambient atmosphere, and the addition of H2O could effectively promote the decarboxylative arylation. Particularly noteworthy is that these results represent the first examples of Pd-catalyzed decarboxylative coupling reactions of (hetero) aromatic carboxylic acids in aqueous medium under air, and the first successful examples of the synthesis of 3-aryl-imidazo[1,2-a]pyridines using cheap, diverse aryl chlorides and heteroaryl chlorides as the starting materials.