934-34-9Relevant articles and documents
Influenza virus replication inhibitors and uses thereof
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Paragraph 0237; 0242-0244, (2021/07/01)
The invention belongs to the field of medicines, and particularly relates to novel compounds serving as an influenza virus replication inhibitor, a preparation method thereof, a pharmaceutical composition containing the compounds and application of the compounds and the pharmaceutical composition in treatment of influenza. The compounds are compounds as shown in a formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or prodrugs of the stereoisomer, the tautomer, the nitrogen oxide, the solvate, the metabolite and the pharmaceutically acceptable salt of the compound as shown in the formula (I). The compounds not only can well inhibit influenza viruses, but also have lower cytotoxicity, excellent in-vivo pharmacokinetic property and the in-vivo pharmacodynamic property and good liver microsome stability.
Au@Cellulose/DFNS for synthesis of thiazolidin-2-ones from arylamines, elemental sulfur and CO2
Wei, Xingyue,Wang, Xingmin
, (2021/04/22)
Turning waste into valuable material is a remarkable phenomenon in sustainable chemistry. However, this reaction is not easy to perform due to the simultaneous employment of two low-reaction raw materials. In this study, we announce the employment of elemental sulfur and CO2 in a multi-element reaction to manufacture valuable thiazolidin-2-ones in the participation of Au@Cellulose/DFNS as a catalyst. In this method, three bonds in one reaction and functional groups with good tolerance were created. To generate the catalyst, DFNS was amended with cellulose through the click reaction and employed as a support for Au nanoparticles. Cellulose acted as both decreasing and consistency medium for Au NPs and removed the need for decreasing agent. The generated catalyst was distinguished by various techniques like XPS, TEM, TGA, SEM, ICP, and XRD analyses.
Benzazoles: III. Synthesis and Transformations of 6-(Chlorosulfonyl)-1,3-benzothiazol-2(3H)-ones
Dushamov, D. A.,Kuryazov, R. Sh.,Mukhamedov, N. S.,Takhirov, Yu. R.
, p. 1519 - 1524 (2020/10/22)
Abstract: Treatment of 1,3-benzothiazol-2(3H)-one andits 3-methyl derivative with chlorosulfonic acid afforded the corresponding2-oxo-2,3-dihydro-1,3-benzothiazole-6-sulfonyl chlorides which reacted withwater, alcohols, and amines to give2-oxo-2,3-dihydro-1,3-benzothiazole-6-sulfonic acids and their esters andamides.