945-03-9

Basic information

• Product Name: (2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID
• Synonyms: IFLAB-BB F1641-0016;(2-OXO-BENZOTHIAZOL-3-YL)-ACETIC ACID;(2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID;2-Oxo-3-benzothiazoleaceticacid;3(2H)-benzothiazoleacetic acid, 2-oxo-;2-(2-keto-1,3-benzothiazol-3-yl)acetic acid;2-(2-oxo-1,3-benzothiazol-3-yl)acetic acid;2-(2-oxo-1,3-benzothiazol-3-yl)ethanoic acid
• CAS NO: 945-03-9
• Molecular Formula: C₉H₇NO₃S
• Molecular Weight: 209.22
• Mol File: 945-03-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID(945-03-9)
• EPA Substance Registry System: (2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID(945-03-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 945-03-9(Hazardous Substances Data)

Usage

General Description

(2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID is a chemical compound with the molecular formula C10H7NO3S. It is a derivative of benzothiazole, a heterocyclic compound containing a benzene ring fused to a thiophene ring. (2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID contains a carboxylic acid group, making it a carboxylic acid derivative. (2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID has potential applications in the pharmaceutical and chemical industries, as it can be utilized in the synthesis of various drugs and organic compounds. Its chemical structure and properties make it a valuable building block for creating diverse molecules with a range of potential biological activities.

Upstream product

• 934-34-9 2(3H)-Benzothiazolone 
• 79-11-8 chloroacetic acid 
• 881-11-8 2-oxo-3(2H)-benzothiazolineacetamide 
• 79-08-3 bromoacetic acid 
• 137-07-5 2-amino-benzenethiol 
• 951-41-7 ethyl (2-oxo-1,3-benzothiazol-3(2H)-yl)acetate 

Downstream Products

• 119584-53-1 3-(benzyloxycarbonylmethyl)-benzothiazoline 
• 72650-17-0 (2-oxo-benzothiazol-3-yl)-thioacetic acid S-benzyl ester 
• 66490-75-3 (2-oxo-benzothiazol-3-yl)-acetic acid N'-phenyl-hydrazide 
• 119584-56-4 (2-oxo-benzothiazol-3-yl)-acetic acid 3-trifluoromethyl-benzyl ester 
• 72650-11-4 (2-Oxo-benzothiazol-3-yl)-thioacetic acid S-phenyl ester 
• 72680-34-3 N-(3-Chloro-phenyl)-2-(2-oxo-benzothiazol-3-yl)-acetamide 
• 72650-13-6 (2-Oxo-benzothiazol-3-yl)-thioacetic acid S-(2,4,5-trichloro-phenyl) ester 
• 72680-38-7 N-(2-Chloro-5-trifluoromethyl-phenyl)-2-(2-oxo-benzothiazol-3-yl)-acetamide 
• 951-40-6 3-(3-diazo-2-oxo-propyl)-3H-benzothiazol-2-one 
• 1210-63-5 3-<2-Oxo-benzothiazol-3-yl>-propionsaeure-methylester 
• 1370283-13-8 C₁₈H₁₇N₃O₃S 
• 1370283-14-9 C₂₁H₂₃N₃O₃S 
• 1370283-15-0 C₁₈H₁₇N₃O₄S 
• 1370283-16-1 C₁₉H₁₉N₃O₃S 

Relevant articles and documents

Anti-nociceptive and anti-inflammatory activity of some (2-benzoxazolone-3-yl and 2-benzothiazolone-3-yl)acetic acid derivatives

Sixteen (2-benzothiazolone-3-yl and 2-benzoxazolone-3-yl)acetic acid derivatives 5 have been tested for anti-nociceptive and anti-inflammatory activity in this study. 4-[2-(6-Benzoyl-2-benzoxazolone-3-yl)acetyl]morpholine (5c), 4-{2-[6-(2-chloro-benzoyl)-

Synthesis and biological activity of some 3-[(4-Amino-5-thioxo-1,2,4- triazol-3-yl)methyl]benzothiazol-2(3H)-one Derivatives

Fourteen new 3-[(4-amino-5-thioxo-1,2,4-triazol-3-yl)methyl]benzothiazol- 2(3H)-one derivatives have been synthesized. The structures of these compounds were confirmed by IR, 1H NMR, mass spectrum and elemental analysis. The synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria and their clinical isolates, for their antifungal activity against Candida albicans and C. krusei and for their antimycobacterial activity against M. tuberculosis H37Rv and its clinical isolate. Some of the compounds showed promising activity.

Synthesis of 2-Oxo-3-benzothiazolineacetyl Chloride (7), 5-Chloro-2-oxo-3-benzothiazolineacetyl Chloride (8) and Derivatives

The reaction of 2-oxo-3-benzothiazolineacetic acid (5) and the 5-chloro analogue 6 with thionyl chloride afforded the titled compounds 7 and 8.The reaction of 7 or 8 with substituted hydrazines, amines or substituted anilines, alcohols and mercaptans furnished the hydrazides 9-14, acetamides and acetanilides 16-21, esters 26-30 and thiolesters 31-37, respectively.Alternate routes for the synthesis of hydrazide 15, acetamides and acetanilides 22-25 and thiolesters 35-36 are described.The reaction of 2-oxo-3(2H)-benzothiazolineacetonitrile with thioacetic acid under acidic conditions afforded 2-oxo-3-benzothiazolineethanethioamide (38).