935-99-9

Basic information

• Product Name: 1-(2-bromo-5-chlorophenyl)ethanone
• Synonyms: 1-(2-bromo-5-chlorophenyl)ethanone;1-(2-Bromo-5-chlorophenyl);Ethanone, 1-(2-bromo-5-chlorophenyl)-
• CAS NO: 935-99-9
• Molecular Formula: C₈H₆BrClO
• Molecular Weight: 233
• Mol File: 935-99-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 155-156 °C(Press: 15 Torr)
• Appearance: /
• Density: 1.566±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-bromo-5-chlorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-5-chlorophenyl)ethanone(935-99-9)
• EPA Substance Registry System: 1-(2-bromo-5-chlorophenyl)ethanone(935-99-9)

Safety Data

• Hazardous Substances Data: 935-99-9(Hazardous Substances Data)

Usage

General Description

1-(2-bromo-5-chlorophenyl)ethanone is a chemical compound with the molecular formula C8H6BrClO. It is a yellow solid that is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 1-(2-bromo-5-chlorophenyl)ethanone is a ketone derivative with a bromine and chlorine atom attached to the phenyl ring, giving it potential applications in organic synthesis and as a building block for creating more complex structures. Its properties and reactivity make it a useful starting material for the preparation of a wide range of organic compounds for various industrial and research purposes.

Upstream product

• 21739-93-5 2-bromo-5-chlorobenzoic acid 
• 75-16-1 methylmagnesium bromide 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 455957-87-6 2-bromo-5-chloro-N-methoxy-N-methylbenzamide 

Downstream Products

• 1370446-90-4 (2-bromo-5-chlorophenyl)(oxo)acetic acid 
• 1260857-12-2 2-bromo-1-(2-bromo-5-chlorophenyl)ethanone 
• 1315568-05-8 6-chloro-4-methyl-3-phenylquinolin-2(1H)-one 
• 455957-88-7 (1R)-1-(2-bromo-5-chlorophenyl)ethanol 

Relevant articles and documents

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Reported here is the development of a class of chiral spirosilabiindane scaffolds by Rh-catalyzed asymmetric double hydrosilation, for the first time. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for the preparation of various chiral ligands and catalysts, was readily prepared on greater than 10 gram scale using this protocol. The potential of this new spirosilabiindane scaffold in asymmetric catalysis was preliminarily demonstrated by development of the corresponding monodentate phosphoramidite ligands (SPSiPhos), which were used in both a Rh-catalyzed hydrogenation and a Pd-catalyzed intramolecular carboamination.

PdII-Catalyzed Oxidative Tandem aza-Wacker/Heck Cyclization for the Construction of Fused 5,6-Bicyclic N,O-Heterocycles

A PdII-catalyzed oxidative tandem cyclization was developed for the construction of fused 5,6-bicyclic N, O-heterocycles. This reaction was enabled by the combined use of a 3-methylpyridine ligand and pentafluorobenzoic acid additive. A range of heterocyclic products with different substituents could be prepared in moderate to good yields via this methodology. Several transformations, including a scaled-up preparation of product 2 a, were also carried out showing the good applicability of our methodology.