938063-63-9Relevant articles and documents
Method for green synthesis of simvastatin side chain (by machine translation)
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Paragraph 0024-0029, (2020/04/17)
The method, comprises the following steps, adding :(1) dimethyl butanoic acid 2,2 - thionyl chloride, to the reaction vessel in a pot method, to carry out the esterification reaction ;(2) to obtain the product (1) dimethyl - 1 1-oxobutyl 3 -methyl propionate, through a solventless method, thereby reducing the material cost 3 - [(2,2 - without using any acid-binding agent) in the esterification step] and reducing the pollution, to the environment by a one-pot, method, at the same time without using any acid-tie-acid-acid-tie-acid-acid methyl ester, to carry out esterification reaction in a solvent concentration step, in the, esterification step by using a solventless method in a step, in the esterification reaction step, to obtain the, product (dimethyl) chloride, in the esterification step. (by machine translation)
Lov-D acyltransferase mediated acylation
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Page/Page column 23, (2016/08/17)
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.