93963-98-5

Basic information

• Product Name: 2,10-dipropionyl-10H-phenothiazine
• Synonyms: 2,10-dipropionyl-10H-phenothiazine;2,10-Bis(1-oxopropyl)-10H-phenothiazine;1,1-(10H-phenothiazine-2,10-diyl)bis(propan-1-one)(WX145614)
• CAS NO: 93963-98-5
• Molecular Formula: C₁₈H₁₇NO₂S
• Molecular Weight: 311.39808
• EINECS: 300-844-2
• Mol File: 93963-98-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 575.2°Cat760mmHg
• Flash Point: 301.7°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 3.12E-13mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 2,10-dipropionyl-10H-phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,10-dipropionyl-10H-phenothiazine(93963-98-5)
• EPA Substance Registry System: 2,10-dipropionyl-10H-phenothiazine(93963-98-5)

Safety Data

• Hazardous Substances Data: 93963-98-5(Hazardous Substances Data)

Usage

Compound class

Phenothiazine

Common use

Synthesis of pharmaceutical drugs

Substituents

Two propionyl (CH3CH2CO) groups on the 2 and 10 positions of the phenothiazine ring system

Reactivity

Versatile

Usage

Building block in the synthesis of various organic compounds

Biological activities

Potential anti-inflammatory and antitumor effects.

InChI:InChI=1/C18H17NO2S/c1-3-15(20)12-9-10-17-14(11-12)19(18(21)4-2)13-7-5-6-8-16(13)22-17/h5-11H,3-4H2,1-2H3

Upstream product

• 92-84-2 10H-phenothiazine 
• 6622-75-9 1-(10H-phenothiazin-10-yl)propan-1-one 
• 79-03-8 propionyl chloride 

Downstream Products

• 3568-24-9 Propionylpromazine 
• 92-33-1 2-propionylphenothiazine 

Relevant articles and documents

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

Given the role of trypanothione in the redox defenses of pathogenic trypanosomal and leishmanial parasites, in contrast to glutathione for their mammalian hosts, selective inhibitors of trypanothione reductase are potential drug leads against trypanosomiasis and leishmaniasis. In the present study, the rational drug design approach was used to discover tricyclic neuroleptic molecular frameworks as lead structures for the development of inhibitors, selective for trypanothione reductase over host glutathione reductase. From a homology-modeled structure for trypanothione reductase, replaced in the later stages of the study by the X-ray coordinates for the enzyme from Crithidia fasciculata, a series of inhibitors based on phenothiazine was designed. These were shown to be reversible inhibitors of trypanothione reductase from Trypanosoma cruzi, linearly competitive with trypanothione as substrate and noncompetitive with NADPH, consistent with ping-pong bi bi kinetics. Analogues, synthesized to define structure-activity relationships for the active site, included N-acylpromazines, 2-substituted phenothiazines, and trisubstituted promazines. Analysis of K(i) and I50 data, on the basis of calculated log P and molar refractivity values, provided evidence of a specially favored fit of small 2-substituents (especially 2-chloro and 2-trifluoromethyl), with a remote hydrophobic patch on the enzyme accessible for larger, hydrophobic 2-substituents. There was also evidence of an additional hydrophobic enzymic region available to suitable N-substituents of the promazine nucleus. K(i) data also indicated that the phenothiazine nucleus can adopt more than one inhibitory orientation in its binding site. Selected compounds were tested for in vitro activity against Trypanosoma brucei, T. cruzi, and Leishmania donovani, with selective activities in the micromolar range being determined for a number of them.