94042-64-5

Basic information

• Product Name: Methanone, (4-chlorophenyl)[4-hydroxy-3,5-bis(1-pyrrolidinylmethyl)phenyl]-
• CAS NO: 94042-64-5
• Molecular Formula: C23H27ClN2O2
• Molecular Weight: 398.933
• Mol File: 94042-64-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanone, (4-chlorophenyl)[4-hydroxy-3,5-bis(1-pyrrolidinylmethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-chlorophenyl)[4-hydroxy-3,5-bis(1-pyrrolidinylmethyl)phenyl]-(94042-64-5)
• EPA Substance Registry System: Methanone, (4-chlorophenyl)[4-hydroxy-3,5-bis(1-pyrrolidinylmethyl)phenyl]-(94042-64-5)

Safety Data

• Hazardous Substances Data: 94042-64-5(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 50-00-0 formaldehyd 
• 42019-78-3 4-chloro-4'-hydroxybenzophenone 

Relevant articles and documents

Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 3. Modifications to the linkage region (region 3)

As part of a continuing program of systematically modifying the structure of the class I antiarrhythmic drug changrolin, we synthesized 15 analogues in which the linkage between the two aromatic regions was altered. High antiarrhythmic activity and low parasympatholytic activity was found when the linkage region, designated region 3, contained a carbonyl moiety, including ketones, amides, and ureas. Secondary amides were superior to tertiary amides, while amide reversal resulted in no change in activities. One compound in this series, 2,6-bis(1-pyrrolidinyl-methyl)-4-benzamidophenol (ACC-9358), is undergoing preclinical evaluations.