947263-58-3

Basic information

• Product Name: 4-acetamido-N-(4-(2-azanorborn-2-yl)butyl)-2-methoxybenzamide
• CAS NO: 947263-58-3
• Molecular Weight: 359.469
• Mol File: 947263-58-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-acetamido-N-(4-(2-azanorborn-2-yl)butyl)-2-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetamido-N-(4-(2-azanorborn-2-yl)butyl)-2-methoxybenzamide(947263-58-3)
• EPA Substance Registry System: 4-acetamido-N-(4-(2-azanorborn-2-yl)butyl)-2-methoxybenzamide(947263-58-3)

Safety Data

• Hazardous Substances Data: 947263-58-3(Hazardous Substances Data)

Upstream product

• 55304-05-7 4-acetylamino-2-methoxy-benzoic acid 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 
• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 279-24-3 2-aza-bicyclo[2.2.1]heptane 
• 947263-49-2 4-(2-azanorborn-2-yl)butyronitrile 
• 947263-53-8 4-(2-azanorborn-2-yl)butane-1-amine 

Relevant articles and documents

Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma

The imaging potential of a series of [123I]benzamides was studied in mice bearing B16F0 melanoma tumors. Compound [123I]25 exhibited tumor uptake >8 %ID/g at 1 h, while that of [123I]14d and [123I]25 reached a maximum of 9-12 %ID/g at 6 h. Standardized uptake values of [123I]14d were higher than 100 between 24 and 72 h after injection. In haloperidol treated animals, the tumor uptake of [ 123I]14d was not significantly different to controls, while significant reduction of [123I]25 uptake was observed, supporting that [123I]14d uptake relates to melanin interaction, whereas part of the mechanism of [123I]25 uptake is related to its σ1-receptor affinity. Benzamides 14d and 25, which display rapid and high tumor uptake, appear to be promising imaging agents for melanoma detection, while 14d, which displays a long lasting and high melanoma/nontarget ratio, is more suitable for evaluation as a potential radiotherapeutic.