95725-03-4

Basic information

• Product Name: Benzamide, 4-cyano-N,N-diethyl-
• CAS NO: 95725-03-4
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.256
• Mol File: 95725-03-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-cyano-N,N-diethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-cyano-N,N-diethyl-(95725-03-4)
• EPA Substance Registry System: Benzamide, 4-cyano-N,N-diethyl-(95725-03-4)

Safety Data

• Hazardous Substances Data: 95725-03-4(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 109-89-7 diethylamine 
• 3058-39-7 4-iodobenzonitrile 
• 617-84-5 N-formyldiethylamine 
• 874-89-5 4-Cyanobenzyl alcohol 
• 121-44-8 triethylamine 
• 126747-14-6 4-cyanophenylboronic acid 
• 187402-80-8 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate 
• 873-74-5 4-Aminobenzonitrile 
• 79664-67-8 4-(3,3-diethyltriaz-1-en-1-yl)benzonitrile 
• 619-65-8 4-cyanobenzoic Acid 
• 58287-77-7 N,N-diethyl-4-formylbenzamide 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 109635-36-1 4-formylbenzonitrile-α-d₁ 
• 105-07-7 4-cyanobenzaldehyde 

Relevant articles and documents

Pd-Catalyst Containing a Hemilabile P,C-Hybrid Ligand in Amino Dicarbonylation of Aryl Halides for Synthesis of α-Ketoamides

The amino dicarbonylation of aryl halides affording α-ketoamides with Pd catalysts is highly dependent on the stereoelectronic properties of the involved ligands. Ionic diphosphine ligand L4 can serve as precursor of a hemilabile P,C (phosphine, carbene)-hybrid ligand to form a stable Pd(II)-complex, Pd-L4. In contrast, analogues L1-L3 with a similar 1-(thiophen-3-yl)-benzimidazolyl skeleton behave as typical (mono/di)phosphines. The catalytic system resulting from the complexation of PdCl2(MeCN)2 and L4 exhibits good catalytic performance in terms of aryl iodides conversion (81-95%) and α-ketoamide selectivity (80-91%), as well as the available recyclability in the RTIL of [Bpy]BF4. The in situ FT-IR analysis reveals that the PdCl2(MeCN)2-L4 catalytic system favors the amino dicarbonylation toward α-ketoamides according to the proposed mechanism of cycle I, which involves two independent CO-insertion steps.

Palladium-Catalyzed N-Acylation of Tertiary Amines by Carboxylic Acids: A Method for the Synthesis of Amides

A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids was achieved through C-N cleavage. This reaction showed a wide substrate scope. Both aromatic and aliphatic acids served well as the acylating reagents and coupled with tertiary amines to produce the corresponding amides in good to excellent yields. With the strategy, bioactive carboxylic acids were also efficiently modified, highlighting the synthetic value of the process in organic synthesis.

Heterogeneous recyclable nano-palladium catalyzed amidation of esters using formamides as amine sources

Catalyzed by supported palladium nanoparticles, a decarbonylative amidation reaction between various aryl esters and formamides by C-O bond activation has been developed for the synthesis of amides. The catalyst can be reused and shows high activity after