96-30-0

Basic information

• Product Name: 2-Chloro-N-methylacetamide
• Synonyms: OTAVA-BB BB7020410071;N-METHYL-2-CHLOROACETAMIDE;2-chloro-n-methyl-acetamid;Acetamide, 2-chloro-N-methyl-;alpha-Chloro-N-methylacetamide;N-Methylchloroacetamide;USAF do-35;usafdo-35
• CAS NO: 96-30-0
• Molecular Formula: C₃H₆ClNO
• Molecular Weight: 107.54
• EINECS: 202-497-1
• Product Categories: Acids and Derivatives
• Mol File: 96-30-0.mol
• Article Data: 26

Chemical Properties

• Melting Point: 38-40°C
• Boiling Point: 112-115°C 20mm
• Flash Point: 110 °C
• Appearance: brown or black
• Density: 1.127 g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.425
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 14.38±0.46(Predicted)
• CAS DataBase Reference: 2-Chloro-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-methylacetamide(96-30-0)
• EPA Substance Registry System: 2-Chloro-N-methylacetamide(96-30-0)

Safety Data

• Statements: 36/37/38-43-22
• Safety Statements: 26-36/37/39-36/37-24
• RTECS: AB5775000
• HazardClass: IRRITANT
• Hazardous Substances Data: 96-30-0(Hazardous Substances Data)

Usage

Uses

2-Chloro-N-methylacetamide is an intermediate used to prepare piperidinylamino pyrrolopyrimidines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.

InChI:InChI=1/C3H6ClNO/c1-5-3(6)2-4/h2H2,1H3,(H,5,6)

Upstream product

• 593-51-1 methylamine hydrochloride 
• 3926-62-3 sodium monochloroacetic acid 
• 79-04-9 chloroacetyl chloride 
• 74-89-5 methylamine 
• 96-34-4 methyl chloroacetate 
• 115525-66-1 (E)-2-Chloro-4,4,5,5,6,6,7,7,7-nonafluoro-3-hydroxy-hept-2-enoic acid methyl ester 
• 115584-92-4 (E)-2-Chloro-4,4,5,5,6,6,6-heptafluoro-3-hydroxy-hex-2-enoic acid methyl ester 
• 50848-97-0 N-chloro-N-methylchloroacetamide 
• 112-41-4 1-dodecene 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 60-51-5 Dimethoate 
• 37744-84-6 dithiophosphoric acid S-(methylcarbamoyl-methyl ester)-O,O'-dipropyl ester 
• 37744-85-7 dithiophosphoric acid O,O'-diisopropyl ester-S-(methylcarbamoyl-methyl ester) 
• 2605-70-1 Dithiophosphorsaeure-O,O'-diaethylester-S-methylaminocarbonylmethylester 
• 57235-84-4 1-methyl-5-chloromethyl-1,2,3,4-tetrazole 
• 500586-84-5 2-tolylsulfonyl N-methylacetamide 
• 888408-40-0 2-(4,7-bis-methylcarbamoylmethyl-10-[(4-([2-(4,7,10-triscarbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-acetylamino]methyl)benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododec-1-yl)acetamide 
• 90497-40-8 α-tritylthio-N-methylacetamide 
• 59721-19-6 N-methylcarbamoylmethyl-p-hydroxyphenylacetate 
• 40828-45-3 2-imino-3-methyl-1-phenyl-imidazolidin-4-one 
• 1196531-35-7 2-(4-(5-cyano-2-methoxyphenoxy)piperidin-1-yl)-N-methylacetamide 
• 298696-30-7 N-{2-[4-(4-Chlorobenzoyl)-1-piperidinyl]ethyl}-3-[2-(methylamino)-2-oxoethoxy]benzamide hydrochloride 
• 848942-61-0 Sapitinib 

Relevant articles and documents

Palladium-Catalyzed β-C(sp3)-H Arylation of Aliphatic Ketones Enabled by a Transient Directing Group

The direct arylation of aliphatic ketones has been developed via Pd-catalyzed β-C(sp3)-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields. Furthermore, the reaction can tolerate abundant substrate of ketones and aryl iodides. This study expands the scope of applications for TDGs.

Method for preparing O, O-dimethyl-S-methylcarbamoylmethyl phosphorodithioate

The invention belongs to the technical field of pesticides, and particularly relates to a method for preparing O, O-dimethyl-S-methylcarbamoylmethyl phosphorodithioate. Chloroacetyl chloride and dimethyl phosphite are used as raw materials to prepare the O, O-dimethyl-S-methylcarbamoylmethyl phosphorodithioate for the first time, the product prepared by using the method is high in yield and purity, no waste liquid is generated in the preparation process, the preparation process is simple, and reaction mother liquor, such as the mother liquor in the step 1 and the step 3, does not need to be treated and can be recycled 6-8 times; while the yield of the product is further improved, the product keeps a high purity, and the quality of the product is ensured. By using the method, through optimization of a reaction system and selection of reaction details, the yield in the reaction in each step can be high. Besides, by using the method, after the reaction is completed, through simple aftertreatment steps, the water content of the obtained product can be as low as 0.032%, and the problem is solved that the product is decomposed due to high water content.

N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES

The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein X, a, b, C, D, L2,L3, Y1, Y2, R2, R4, R5, R6, z2, z4, z5, and z6 are as defined herein, and salts thereof. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to compounds for use in methods of inhibiting the ATF4 (activating transcription factor 4) pathway and treatment of disorders associated therewith, such as e.g. cancer, neurodegenerative diseases and many other diseases, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. Preferred compounds of the invention are N-(3-(2-(4-chlorophenoxy) acetamido)bicyclo[1.1.1]pentan-l-yl)-2-cyclobutane-l-carboxamide derivatives and related compounds.